KDM5A

KDM5A

A gene on chromosome 12p11 that encodes lysine-specific demethylase 5A, which is a ubiquitously expressed nuclear protein. It forms a complex with other proteins, binding to retinoblastoma protein and regulating cell proliferation.
References in periodicals archive ?
Barbieri et al., "The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma," Cell Cycle, vol.
The histone methyltransferases (SET1, G9a, SUV39H1, and SUV39H2) and the histone demethylases (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) gene expression was detected by real-time quantitative PCR.
In order to investigate the cause of altered histone methylation patterns in LADA patients, we assessed mRNA levels of histone methyltransferases (SET1, G9a, SUV39H1, and SUV39H2) and the histone demethylases (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) in [CD4.sup.+] T lymphocytes by real-time quantitative PCR.
Histone 3 lysine 4 methylation was regulated by histone methyltransferase SET1 and histone demethylase LSD1, KDM5A, KDM5B, KDM5C, and KDM5D.
The mRNA level of histone methyltransferases gene (SET1, SUV39H1, SUV39H2, and G9a) and histone demethylases gene (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) was detected by real-time PCR.
(b) Relative mRNA levels of histone demethylases (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) in [CD4.sup.+] T lymphocytes from LADA patients (n = 26) and healthy controls (n = 26), the absolute of fold change > 2 was considered significant, LADA patients versus healthy controls; data are normalized against beta-actin.
In addition to these LXCXE proteins, pRB interacts with many nuclear proteins independently of the LXCXE motif, such as histone methyl transferase Suv39h1 [15, 17], histone demethylase LSD1 [18], and histone demethylase RBP2 (KDM5A) [19, 20].
Benevolenskaya, "Increased mitochondrial function downstream from KDM5a histone demethylase rescues differentiation in pRB-deficient cells," Genes & Development, vol.
Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens.
The Salk researchers and their collaborators at McGill University and Albert Einstein College of Medicine describe how the gene KDM5A encodes a protein, JARID1a that serves as an activation switch in the biochemical circuit that maintains our circadian rhythm.