KDM4B

KDM4B

A gene on chromosome 19p13.3 that encodes lysine-specific demethylase 4B, which demethylates histone H3; it generates formaldehyde and succinate and acts as a transcription repressor.
References in periodicals archive ?
He and his team found that KDM4B and KDM6B, two gene-activating enzymes, can promote stem cells' differentiation into bone cells by removing methyl markers from histone proteins.
The research group, through its study of aging mice, found that the two enzymes KDM4B and KDM6B could specifically activate genes that promote stem cell differentiation toward hone, while blocking the route toward fat.
Interestingly, in our aged mice, as well as osteoporotic mice, we observed a higher amount of silencing histone methyl groups which were normally removed by the enzymes KDM4B and KDM6B in young and healthier mice," Wang said.