KDM3A

KDM3A

A gene on chromosome 2p11.2 that encodes lysine-specific demethylase 3A, which demethylates histone H3. KDM3A is involved in hormone-dependent transcriptional activation, spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 (which are required for packaging), and condensation of sperm chromatin. It is also involved in obesity resistance by regulating metabolic genes (e.g., PPARA and UCP1).
References in periodicals archive ?
The histone methyltransferases (SET1, G9a, SUV39H1, and SUV39H2) and the histone demethylases (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) gene expression was detected by real-time quantitative PCR.
In order to investigate the cause of altered histone methylation patterns in LADA patients, we assessed mRNA levels of histone methyltransferases (SET1, G9a, SUV39H1, and SUV39H2) and the histone demethylases (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) in [CD4.sup.+] T lymphocytes by real-time quantitative PCR.
Histone 3 lysine 9 methylation was regulated by histone methyltransferase G9a, SUV39H1, SUV39H2, and histone demethylase LSD1, KDM3A, KDM3B, KDM4A, KDM4B, and KDM4C [20, 21].
The mRNA level of histone methyltransferases gene (SET1, SUV39H1, SUV39H2, and G9a) and histone demethylases gene (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) was detected by real-time PCR.
(b) Relative mRNA levels of histone demethylases (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) in [CD4.sup.+] T lymphocytes from LADA patients (n = 26) and healthy controls (n = 26), the absolute of fold change > 2 was considered significant, LADA patients versus healthy controls; data are normalized against beta-actin.
KDM3a bides within the SWI/SNF complex in the chromatin and controls the activity of the [beta]1-adrenergic receptor [103].
We have also shown that Ni increases H3K9me2 by inhibiting the demethylating activity, by directly binding and replacing the iron(II) from the enzyme JHDM2A/JMJDIA (KDM3A), with no observable effect on methyltrans-ferases (Chen et al.