KDM2A

KDM2A

A gene on chromosome 11q13.2 that encodes lysine-specific demethylase 2A of the F-box protein family, which constitute one of the four subunits of the ubiquitin protein ligase complex called SCF (SKP1-cullin-F)-box (which is involved in phosphorylation-dependent ubiquitination). KDM2A may recognise and bind phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs, which are encoded by clusters of satellite repeats at the centromere. It is needed to sustain centromeric integrity and genomic stability, especially during mitosis.
References in periodicals archive ?
The mRNA expression levels of KDM2A, KDM2B, and EZH2 were higher in TNF-[alpha]-treated cells compared to control cells, and AZM mitigated this effect (Figure 3(g)-3(i)).
The histone lysine demethylases (KDMs) KDM2A and KDM2B demethylate H3K4me3 and H3K36me1/2 [50].
Abbreviations BSP: Bone sialoprotein EZH2: Enhancer of zeste homolog 2 FBS: Fetal bovine serum FITC: Fluorescein isothiocyanate KDM2A: Lysine-specific demethylase 2A KDM2B: Lysine-specific demethylase 2B OCN: Osteocalcin PI: Propidium iodide Runx2: Runt-related transcription factor 2.
that KDM2A plays an important role in repressing centromeric satellite repeats; however, the specificity of the repression on chromosomal centromeric repeats was not further narrowed down [17].
Kuchay et al., "KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state," Cell Cycle, vol.