KCNQ3

KCNQ3

A gene on chromosome 8q24 that encodes a protein which, with the KCNQ2 protein product, forms the M channel, a slowly activating and deactivating potassium channel central to regulating neuronal excitability.

Molecular pathology
KCNQ2 mutations are associated with benign familial neonatal seizures type 2 (e.g., benign familial neonatal convulsions).
References in periodicals archive ?
Benign familial neonatal convulsions (BFNC) are associated with a family history of neonatal convulsions and occur in an autosomal dominant pattern: potassium channel genes are associated with this disorder--KCNQ2 and KCNQ3.
Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.
Moreover, mutations in KCNQ2 and KCNQ3 genes have been shown to be associated with benign familial neonatal convulsions (54,55).