Six other genes (CACNA1C, CACNB2, SCN1B, KCNQ3
, SCN3B, and HCN4) have been associated with BrS, but the prevalence of variants in these genes is yet unknown (6).
In human bodies, ankyrins have been confirmed to bind to the voltage-gated potassium channel subunits KCNQ2 and KCNQ3
, regulating their normal functions .
Benign familial neonatal convulsions (BFNC) are associated with a family history of neonatal convulsions and occur in an autosomal dominant pattern: potassium channel genes are associated with this disorder--KCNQ2 and KCNQ3
. Seizures usually occur for two to three months, and then stop.
In animals with binocular vision, fluoxetine promoted an increase in the expression of CLCN3 (20% increased), KCNV1 (20% increased), and KCNQ3
(30% increased), which encode ion channels that mediate chloride and potassium conductance (P < 0.05), and in animals with monocular deprivation fluoxetine produced also an increase in the expression of CLCN3 (50% increased expression; P = 0.01).
Mouse models of human KCNQ2 and KCNQ3
mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.