Overall, genes with which DM sites were associated include (but are not limited to) those having functions in chromatin compaction (NAT15; HDAC4; UHRF1); DNA damage/repair or chromosomal segregation (SOD3; UHRF1; NAT15); muscle contraction (NR4A3; HDAC4; FEZ1; PRKG1; KCNH7
); axonal bundling/outgrowth (FEZ1); cell signaling in muscle (NR4A3; PRKG1); neuronal excitability/synaptic transmission (BDNF; BZRAP1; EPHA5; KCNH7
); muscle maturation (HDAC4); response to oxidative stress (SOD3); and inflammatory processes (AXL; SH2B2).
Category Group Regulated core genes Cardiac hypertrophy WB TPM1.FGF23 Cardiac hypertrophy Imipramine EPO, UCN2, TERT, VDR, ACE Cardiac arrhythmia lmipramine ATP1A3, SCN1A, KCNH7
, KCNG2, KCNQ1, ADORA1, ADRA1B, ADRB3, ADRA1D Cardiac adenopathy EtOH-Fr DLCAP4, MTHFS, EVC2, MAPK9.