KB-141

KB-141

A synthetic form of thyroid hormone that stimulates the receptors that mainly increase the metabolic rate and lower LOW-DENSITY LIPOPROTEINS without increasing the heart rate. KB-141 has been shown to be effective in substantially reducing the weight of monkeys on a fixed diet.
References in periodicals archive ?
Oral administration of MB07811 caused liver-specific exposure, with minimal effect on gene expression in extrahepatic tissues and showed an improved safety profile as compared to T3 and KB-141.
The studies showed that in rodent models, MB07811 significantly lowered LDL-cholesterol (the "bad" cholesterol) and plasma triglyceride levels as well as liver fat, with an acceptable safety profile and an improved therapeutic index as compared to non liver-targeted TR agonists, T3 and KB-141.
The studies in rats and mice showed an improved safety profile, including no cardiac effects and reduced effects on the thyroid hormone axis compared to KB-141.