KAT7

KAT7

A gene on chromosome 17q21.32 that encodes a component of the HBO1 complex which is responsible for the bulk of histone H4 acetylation. KAT7 specifically represses AR-mediated transcription; it may regulate DNA replication by chromatin acetylation and act as a coactivator of TP53-dependent transcription.
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References in periodicals archive ?
As the HAT Kat6b was identified in this study as a potential target of miR-487b, we examined the effects of LPS on the expression of Kat6b and also of the other members of the Kat family of HATs (Kat6a, Kat5, Kat7, and Kat8).
The recombinant KAT7 (Hbo1 purified from Sf9 cells), MurFl, GST-tagged p53, and ubiquitin proteins were purchased from Active Motif (Carlsbad, CA, USA), R&D systems (Minneapolis, MN, USA), EMD Millipore (Temecula, CA, USA) and UBPBio (Aurora, CO, USA), respectively.
Current science with KAT7 by Nadeem Oozeer and Sharmila Goedhardt (SKA)
The site is already home to seven massive Gregorian dish antennas that form part of the Karoo Array Telescope, or Kat7.