KAT6A


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KAT6A

A gene on chromosome 8p11 that encodes a histone acetyltransferase which acetylates lysine residues in histone H3 and histone H4. KAT6A is part of the MOZ/MORF complex which has histone H3 acetyltransferase activity. It may act as a transcriptional coactivator for RUNX1 and RUNX2.
 
Molecular pathology
Defects in KAT6A have been linked to acute myeloid leukaemias and myelodysplastic syndrome by various translocations resulting in oncogenes and fusion proteins.
References in periodicals archive ?
In summary, we have found that the HAT Kat6B is strongly suppressed in macrophages by LPS (M1 activation), while Kat6A is reciprocally upregulated.
Caption: Figure 3: The expression of MYST family HATs (Kat6B, Kat6A, Kat5, Kat7, and Kat8) was determined using TaqMan Q-RT-PCR assays, with RNA samples from untreated macrophages or macrophages treated with LPS (100ng/ml), NECA (1 [micro]M), or LPS (100ng/ml) with NECA (1 [micro]M) for 3, 6, 12, and 24 hours.
"Even though Daniel has KAT6A syndrome, he is our happy little boy who will always have a go at anything.
"As the KAT6A gene change was not found in his parents, this also means that the likelihood of future children having the KAT6A mutation is very low."