KAT2B

KAT2B

A gene on chromosome 3p24 that encodes a ubiquitously expressed enzyme which has significant acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. KAT2B inhibits cell cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. It is recruited by HIV-1’s Tat protein; it may regulate its transactivating activity and help induce chromatin remodelling of proviral genes. KAT2B is most abundant in the heart and in skeletal muscle.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The two main members, GCN5 (general control nonderepressible 5, KAT2A) and pCAF (p300/CBP-associated factor, KAT2B), are closely related proteins playing an important role in gene transcription.
Buxton et al., "Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development," Journal of Molecular and Cellular Cardiology, vol.
HUANG_FOXA2_TARGETS_UP comprises 45 genes, some of which have been suggested to be implicated in the development of diabetes, such as KAT2B and TNFAIP3.
Moreover, the DNA-PK compound and KAT2B were shown to interact with PDX1, CREB1, and EP300, leading to the induction of IPCs and generation of insulin [30].
cerevisiae); NAD-dependent BRCA1 Breast cancer 1, early onset; the BRCA1-BARD1 0.999 heterodimer coordinates a diverse range of cell pathways such as DNA damage repair, ubiquitination, and transcriptional regulation to maintain genomic stability CDKN1B Cyclin-dependent kinase inhibitor 1B (p2, Kip1); 0.999 important regulator of cell cycle progression KAT2B K(lysine) acetyltransferase 2B; it has histone 0.999 acetyl transferase activity with core histones and nucleosome core particles Figure 9: Validated drugs.