KAT2AA gene on chromosome 17q12-q21 that encodes a ubiquitously expressed histone acetyltransferase, which acts primarily as a transcriptional activator. KAT2A also downregulates NF-kappB by promoting ubiquitination of the NF-kappB subunit RELA in a HAT-independent manner. It is recruited by HIV-1’s viral Tat protein, regulates Tat's transactivating activity, and may help induce chromatin remodelling of proviral genes.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.