KAT2A

KAT2A

A gene on chromosome 17q12-q21 that encodes a ubiquitously expressed histone acetyltransferase, which acts primarily as a transcriptional activator. KAT2A also downregulates NF-kappB by promoting ubiquitination of the NF-kappB subunit RELA in a HAT-independent manner. It is recruited by HIV-1’s viral Tat protein, regulates Tat's transactivating activity, and may help induce chromatin remodelling of proviral genes.
References in periodicals archive ?
The two main members, GCN5 (general control nonderepressible 5, KAT2A) and pCAF (p300/CBP-associated factor, KAT2B), are closely related proteins playing an important role in gene transcription.
Buxton et al., "Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development," Journal of Molecular and Cellular Cardiology, vol.