KRAS

(redirected from K-ras p21 protein)

KRAS

A Kirsten ras oncogene homolog from the mammalian ras gene family on chromosome 12p12.1, which encodes a small GTPase in which a single amino acid substitution results in a transforming protein.

Molecular pathology
The KRAS transforming protein has been linked to various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas, colorectal carcinoma, acute myelogenous leukaemia, juvenile myelomonocytic leukaemia, gastric cancer, pilocytic astrocytoma, Noonan syndrome type 3, and cardiofaciocutaneous syndrome
References in periodicals archive ?
Roughly 90% of the activating mutations, that are influential solitary amino acid replacement in the GTPase pocket that guide to a block of the activity of K-ras p21 protein, are recognized in codons 12 (GGT) and 13 (GGC) of exon 1 and almost 5% in codon 61 (CAA) situated in exon 2.