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Several protein kinases such as protein kinase C, Jun N-terminal kinase, p38, and mTOR may also be responsible for STAT3 (ser727) phosphorylation [24, 26, 30, 38-40].
Therefore, we studied the involvement of iron and ROS in the modulation of Jun N-terminal kinase 2 (JNK2) activity, c-jun and c-fos mRNA levels, key signaling steps in the transcriptional control of matrix-degrading metalloprotease (MMP)-1/interstitial collagenase and MMP-3/stromelysin-1 after UVB irradiation of human dermal fibroblasts in vitro.