Especially, one TF, Jumonji
, contained the CpG_2, suggesting that it may influence the CD4 gene expression through the potential binding of the predicted TFs.
Current study by Bustos and colleagues have demonstrated that JARID1B (Jumonji
AT-rich interactive domain 1B) histone demethylase represses Runx2 in undifferentiated WJ-MSCs.
Indeed, glutamine supports alternative polarization by favoring Jmjd3- (jumonji
domain containing -3-) dependent demethylation on the promoters of M2associated genes.
Members of the 2-ketoglutarate-dependent dioxygenase family include prolyl hydroxylase domain proteins (PHDs), ten-eleven translocation (TET) enzymes, and Jumonji
C domain-containing histone lysine demethylases.
These strategies include the targeting of the histone demethylase jumonji
, AT rich interactive domain 1B (JARID1B), which we found to be functionally significant in the maintenance of cancer stem cells.
Thomas, "Nitric oxide modifies global histone methylation by inhibiting Jumonji
C domain-containing demethylases," Journal of Biological Chemistry, vol.
This occurs through the inhibition by D-2-hydroxyglutarate of the jumonji
histone lysine demethylases (KDM) and of the TET-hydroxylases that convert 5-methylcytosine into 5-hydroxyl-methylcytosine thus leading to the accumulation of 5-methylcytosine.
Genetic knockout of the Jumonji
C-domain containing protein (Jhdm2a), a H3K9 demethylase, is able to increase mice susceptibility to obesity by abnormal fat deposition and hyperlipidaemia, likely due to PPAR[alpha] expression decrease in skeletal muscles and brown fat .
These epigenetic regulators include such factors as histone demethylase, Jumonji
D3, and microRNA let-7c.
(2) Institute of Food, Nutrition and Health, Jumonji
University, 2-1-28 Sugasawa, Niiza, Saitama 3528510, Japan
 demonstrated that RANKL stimulation upregulated the jumonji
domain-containing 3 (jmjdy) gene, and short hairpin RNAs of jmjd3 gene diminished RANKL-induced osteoclast differentiation, suggesting that JMJD3, a H3K27 demethylase, plays an important role in osteoclast differentiation.