A nuclear protein critical for normal cardiovascular, nervous system, liver, spleen, and thymus development. JMJ knockout mice embryos have major heart malformations—e.g., ventricular septal defect, noncompaction of the ventricular wall, double outlet right ventricle, and dilated atria—and die soon after birth. In adult mice, JMJ is expressed at a higher level in heart, skeletal muscle, brain, and thymus. JMJ may be involved in cell growth when it is over-expressed, and may be a transcription factor.
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ELF6 and REF6 are Jumonji N/C (Jmj N/C) domaincontaining proteins known to regulate flowering time.
Modulation of brassinosteroid-regulated gene expression by Jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis.
Macrophage stimulation using the cytokine IL-4 and LPS also induced expression of an H3K27 histone lysine demethylase enzyme called Jumonji Domain Containing-3 (JmjD3/Kdm6b), causing transcription of specific M2-associated genes (De Santa et al.
In addition, we observed down-regulation of DNA methyltransferase 1 (Dnmt1) and suppressor of variegation 3-9 homolog 1, a histone lysine methyltransferase (Suv39h1), and up-regulation of the histone demethylase Jumonji domain 2 (Jmjd2a), proteins responsible for the accurate maintenance of the epigenetic marks.
Glad to be free, Harry Jumonji grabs a gray slide for Hosoi in Brooklyn.
M4, 6-9) Toyonoshima (M10, 8-7) M10 Iwakiyama (M1, 2-13) Jumonji (J2, 13-2) M11 Tamakasuga (M14, 9-6) Tochinohana (M13, 8-7) M12 Toyozakura (M8, 5-10)