The disease was initially referred to as Job's syndrome, with reference to Biblical Job who was "smote with boils." The autosomal dominant form is caused by mutations in the STAT3 gene which is a major signal transduction protein involved in wound healing, angiogenesis, immune pathways, and cancer .
Tarhan et al., "The development of pulmonary adenocarcinoma in a patient with Job's syndrome, a rare immunodeficiency condition," Tumori, vol.
RESULTS: Pyodermas clinical types (7) incidence--Of the 100 cases studied Impetigo 30% was the most commonest clinical type followed by Folliculitis (22%), Furunculosis (10%), Ecthyma (6%), Infected scabies (5%), Sycosisbarbae (5%), Erythrasma (5%), Cellulitis (3%), Infectious Eczematous Dermatitis (3%), Paronychia (3%), Carbuncle (2%), Periportis (2%), Infected wound (2%), Job's syndrome
(1%), Pitted keratolysis (1%).