SMAD4

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SMAD4

A gene on chromosome 18q21.1 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD4 forms homomeric complexes and heteromeric complexes with other activated SMADs; these accumulate in the nucleus and regulate target gene transcription. SMAD4 binds to DNA and recognizes an 8-bp palindromic sequence, the SMAD-binding element (SBE).
 
Molecular pathology
SMAD4 mutations or deletions are linked to hereditary haemorrhagic telangiectasia syndrome, juvenile polyposis syndrome and pancreatic cancer.
References in periodicals archive ?
Moreover, it is the only terminal at JIP capable of fully accommodating ultra-large container ships of 14,000+ TEU capacity.
Different matters like land acquisition, recruitment of project implementation consultants, structures on JIP canal system and others were discussed in the meeting.
He said that former JIP chief late Qazi Hussain Ahmad was a brave leader who struggled against corruption and corrupt individuals all his life.
The proposed tender offer price of JPY 2,503 per share and the share repurchase price of JPY 1,710.34 per share have been determined based on negotiations among KKR, Hitachi, and JIP.
The work of the PETGAS JIP could in time play a key role in unlocking the significant, yet untapped, potential of stranded gas resources in the Southern North Sea and beyond.
"We are very encouraged by the formation of the JIP's Joint Management Team (JMT) and will work closely with the JMT and other international donors to ensure that the JIP can meet its mandate," it said.
Additionally, CD-adapco provided software (STAR-CCM+) and carried out simulations in support of the JIP.
WIN WIN, a DNV GL-led joint industry project (JIP), is running with the following seven participants: ExxonMobil, ENI Norge, Nexen Petroleum UK Ltd, Statoil, VNG, PG Flow Solutions, and ORE Catapult.
JIP Welcomes Maersk Mega Ship : In June, the Red Sea Gateway terminal at the Jeddah Islamic Port (JIP) welcomed the Maersk Line vessel the MV Mayview Maersk, one of the largest ships in the world.
The new infrastructure projects include the Jeddah Islamic Port (JIP) expansion, which is expected to increase the handling capacity of the port by 45%.
According to Bloomberg, new mega Saudi port projects include Jeddah Islamic Port (JIP) which is currently undergoing an expansion project, which will eventually increase capacity by 45 per cent.
The new Saudi Arabian port projects include the Jeddah Islamic Port (JIP) expansion which will increase the capacity by 45 per cent, according to Bloomberg.