In the first paragraph of this "weretale for six actors, five voices, two players," narrator Jerne
Voltampere proffers fair warning: "Reader, do not doubt the truth of my words, for the tale I tell is a lie from beginning to end.
This era was the early 1980s, when Cesar Milstein, Niels Jerne
, and Georges Kohler received the Nobel Prize in physiology or medicine (1984) for the "discovery of the principle for the production of monoclonal antibodies.
Immune networks had been proposed by Jerne
 as networks of mutually interacting and cooperative 'idioytpes' and 'anti-idiotypes' as regulators of immune response towards antigenic approaches through which the antigen itself reveals a 'meaning'.
No body process is simple, but the immune system is so terrifically complex that Nobel laureate Niels Jerne
once likened it to a foreign language operating independently of the brain.
The Immune Network Model was proposed by Jerne
, and it is a mathematical model of the immune system.
No less than three Nobel Prizes were awarded to people connected with the Institute for Immunology--Niels Jerne
, Georges Kohler and Susumu Tonegawa--which Roche founded in 1969.
They include the following (with the number of consecutive years each restaurant has earned the award); Saddle Peak Lodge, Calabasas (six years); Gennaro's Ristorante, Glendale (three years); the Dining Room (Regent Beverly Wilshire hotel, Beverly Hills - eight years); Gardens (Four Seasons Hotel, Los Angeles - eight years); Patina, Los Angeles (12 years); the Restaurant (Hotel Bel-Air - five years); L'Orangerie, Los Angeles (two years); jerne
restaurant (Ritz-Carlton Hotel, Marina del Rey - two years); Valentino, Santa Monica (eight years); Diaghilev (Wyndham Bel Age Hotel, West Hollywood - 11 years).
They include Jonas Salk, who discovered the polio vaccine; Niels Jerne
, who received the Nobel Prize in Medicine for his ground-breaking research on the formation of monoclonal antibodies; Frank Dixon, recipient of the prestigious Lasker Award for his outstanding contribution to the creation of the medical discipline, immunopathology; Thomas Starzl, who founded the most prominent solid organ transplant program in the world; and Ronald Herberman, who discovered natural killer cells - important components of the immune system.
About 270 people attended, including James Watson, Francis Crick, Macfarlane Burnet, Niels Jerne
, Gerald Edelman, Cesar Milstein, and Baruj Benacerraf--all previous or future Nobel Prize winners.
Immune System: Edelman won the 1972 Nobel Prize for confirming a Darwinian theory of the immune system previously suggested by MacFarlane Burnet and Niels Jerne
NK, Nordin AA (1963) Plaque formation in agar by single antibody producing cells.
Self organization: the memory cells are organized into so-called idiotypic network (a hypotheses stated by Jerne
, 1974) that changes in time.