Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan) (KBG) is one of the prescriptions in Japanese traditional medicine for improving the "oketsu" syndrome, so-called blood stasis syndrome.
"Oketsu", blood stasis syndrome, is one of the pathological concepts unique to Japanese traditional medicine. In Japanese traditional medicine, "ketsu" ("Xue" or blood), means human red body fluid containing life energy ("ki" or "Qi"), that circulates in the body.
Keishi-bukuryo-gan (KBG: Gui-Zhi-Fu-Ling-Wan), one of the prescriptions in Japanese traditional medicine for improving the "oketsu" syndrome, exerts some favorable pharmacological effects on improving a conjunctival microcirculation (Itoh et al., 1988), inhibiting a platelet aggregation, suppressing the production of Thromboxane A2 in platelets, and decreasing blood viscosity (Tosa et al., 1987) and RBC aggregability (Kohta et al., 1993).
The "oketsu" score was determined by two of the authors, both specialists in Japanese traditional medicine. "Oketsu" score, RBC deformability, and intracellular ATP content were measured at 0 (immediately before administration) and 4 weeks after administration.
This prescription is one of the most popular prescriptions for improving the "oketsu" syndrome in Japanese traditional medicine, and has the effect of improving hemorheological parameters such as blood viscosity and RBC aggregability.