JAK1

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JAK1

A gene on chromosome 1p32.3-p31.3 that encodes a non-receptor protein tyrosine kinase involved in the IFN-alpha/beta/gamma signal pathway, which is further characterised by a second phosphotransferase-related domain immediately N-terminal to the PTK domain.
References in periodicals archive ?
12- and 24-Week Patient-Reported Outcomes from a Phase IIb Dose-Ranging Study of Baricitinib, an Oral Janus Kinase 1 / Janus Kinase 2 Inhibitor, in Combination with Traditional Disease-Modifying Antirheumatic Drugs in Patients with Rheumatoid Arthritis
24-Week Results of a Blinded Phase IIb Dose-Ranging Study of Baricitinib, an Oral Janus Kinase 1 / Janus Kinase 2 Inhibitor, in Combination with Traditional Disease Modifying Antirheumatic Drugs in Patients with Rheumatoid Arthritis
JAKAFI is a selective Janus kinase 1 (JAK1) and JAK2 inhibitor developed and marketed in the US by Incyte Corporationand internationally by Novartis.
GSK2586184 is a Janus kinase 1 (JAK1) inhibitor, which is developed within Galapagos's inflammation alliance withA GSK.