warfarin

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warfarin

 [wor´fah-rin]
a synthetic coumarinanticoagulant, usually used as the sodium salt; administered orally or intravenously. It is also used as a rodenticide, causing fatal hemorrhaging in any mammal that consumes a sufficient dose, including humans.

war·fa·rin

(wōr'fă-rin),
An anticoagulant with the same actions as dicumarol; also used as a rodenticide; also available as the potassium salt, with the same actions and uses.

warfarin

(wôr′fər-ĭn)
n.
A white crystalline compound, C19H16O4, that inhibits production of prothrombin and is used in the form of its sodium salt as an anticoagulant drug and as a rodenticide.

warfarin

An anticoagulant that inhibits synthesis of liver-dependent coagulation factors (the prothrombin complex, factors II, VII, IX and X), which are formed by gamma-carboxylation of precursor proteins.
 
Indications
Prevention of uncomplicated distal DVT, prophylaxis and prevention of thromboembolism, post-acute myocardial infarction.

Monitoring
Warfarin therapy is monitored by serial evaluation of PT–2-3-fold > normal 12–16 seconds; its activity is increased by phenylbutazone, clofibrate (by outcompeting with warfarin for plasma-protein binding sites and decreased by barbiturates, which stimulate hepatic metabolism).

warfarin

Coumadin Hematology An anticoagulant that inhibits synthesis of liver-dependent coagulation factors–the prothrombin complex, factors II, VII, IX and X, which are formed by γ-carboxylation of precursor proteins Indications Prevention of uncomplicated distal DVT, prophylaxis and prevention of thromboembolism, post-acute MI; warfarin therapy is monitored by serial evaluation of PT–2-3-fold > normal 12–16 secs; its activity is ↑ by phenylbutazone, clofibrate–by outcompeting with warfarin for plasma protein binding sites and ↓ by barbiturates, which stimulate hepatic metabolism. See Superwarfarin. Cf Heparin.

war·fa·rin

(wōr'fă-rin)
An anticoagulant and rodenticide.

warfarin

An ANTICOAGULANT drug used to prevent blood from clotting in the blood vessels. The drug is on the WHO official list. A brand name is Marevan.

Warfarin

A drug given to control the formation of blood clots. The PT test can be used to monitor patients being treated with warfarin.

Warfarin,

Wisconsin Alumni Research Foundation (WARF).
Warfarin - oral anticoagulant, named for the foundation.

war·fa·rin

(wōr'fă-rin)
Anticoagulant with same actions as dicumarol.

Patient discussion about warfarin

Q. how medications effect me side effects warfarin,s effect what does I and R mean i have my I and R each week, what is it,s function..........

A. It depends what the heart condition is but probably not. Not being on warfarin may increase your risk of stroke. Most importantly you need to address this wuestion with the doctor that prescribe the warfarin to you.

More discussions about warfarin
References in periodicals archive ?
Two of the newest additions to the Upsher-Smith product line are Folgard OS and Jantoven.
Jantoven, the most recent item added to the cardiovascular product line at Upsher-Smith, is a warfarin sodium formulation in tablet form.