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Norplant is a long-acting hormone that is inserted under the skin and prevents conception for up to five years. Depo-Provera is also a hormone, but is administered by intramuscular injection and provides protection against pregnancy for three months. Lunelle is another injectable contraceptive that is administered monthly (every 28 to 30 days); it was approved by the Food and Drug Administration (FDA) in October 2000. The hormone in Norplant and Depo-Provera is progestin, a synthetic hormone similar to one found naturally in a woman's body; Lunelle contains the hormones progestin and estrogen.


The purpose of these hormones is to prevent pregnancy; they are about 99% effective in achieving this goal. No hormonal contraceptive methods provide protection from AIDS or other sexually transmitted diseases.
Depo-Provera and Lunelle are given as an injection and work in several ways to prevent conception. First, the egg (ovum) is prevented from maturing and being released. The mucus in the cervix (opening into the uterus or womb) becomes thicker, making it difficult for the sperm to enter. Depo-Provera and Lunelle also cause the lining of the uterus to become thinner, making implantation of a fertilized egg unlikely.
An injection of Depo-Provera or Lunelle must be given within the first five days of a normal period. Depo-Provera provides protection against pregnancy for three months, while Lunelle provides similar protection for one month. Ovulation (release of a mature egg) typically occurs within 60 days of the last injection of Lunelle, about twice as fast after use of Depo-Provera. Also, because Lunelle is a combined hormone contraceptive as opposed to progestin-only Depo-Provera and Norplant, it is less likely to cause irregular or absent menstruation.
Norplant capsules contain a synthetic hormone that is slowly released over a period of up to five years. It functions like Depo-Provera in that it prevents the ovaries from producing ova (eggs) and also results in thicker mucus in the cervix, which prevents the sperm from passing through the cervix. Norplant can be inserted at any time.


The woman being considered for Depo-Provera or Lunelle will have a pelvic and breast examination, a Pap test (a microscopic examination of cell samples taken from the cervix), blood pressure check, weight check, and a review of her medical history. Women who have diabetes mellitus, major depression, blood clotting problems, liver disease, or weight problems should use these methods only under strict medical supervision. Depo-Provera or Lunelle should not be used if the woman is pregnant, has unexplained vaginal bleeding, suffers from severe liver disease, has breast cancer, or has a history of blood clots or stroke.
Individuals who select Norplant will receive the same basic physical examination. If approved for this method, a site of implantation will be selected (usually the inside of the upper arm), and the area prepared for minor surgery. The skin will be washed with soap and water, and an antiseptic, such as iodine solution, will be applied. The physician will use a local anesthetic to numb the area, a small incision will be made, the six Norplant capsules will be inserted, and the incision sewn up (sutured). Protection against pregnancy normally begins within 24 hours. If necessary, the implants can be removed in 15-20 minutes. Norplant should not be used by women who are pregnant, have blood clotting problems, or have unexplained vaginal bleeding. Advantages include light periods with less cramping and decreased anemia. This form of birth control may also be protective against endometrial cancer.
Because Depo-Provera and Norplant use only the hormone progestin, they may provide an alternative for women who can not use estrogen-containing birth control pills. One benefit of Lunelle, however, is that its effects wear off more quickly than Depo-Provera, an important factor in the event that a woman has serious side effects or wants to become pregnant.

Key terms

Hormone — A chemical produced in a gland or organ and transported by the blood to another area of the body where it produces a specific effect.
Pap test — A microscopic examination of cell samples taken from the cervix.


The most common side effects associated with Depo-Provera and Lunelle are yellowing of the skin, headache, nervousness, dizziness, abdominal pain, hair loss, rash, increase in the number of migraine headaches, increased or decreased interest in sexual intercourse, the development of dark spots on the skin, depression, and weakness. Danger signs that need to reported immediately include weight gain, heavy vaginal bleeding, frequent urination, blurred vision, fainting, severe abdominal pain, and coughing up blood. Because the effects of Depo-Provera may last up to 12 weeks, it may take a longer time for women trying to conceive to become pregnant after discontinuing the injections.
The main reactions to Norplant include headache, weight gain, irregular periods or no period at all, breast tenderness, acne, gain or loss of facial hair, color changes of the skin over the area of insertion, and ovarian cysts. The doctor should be notified immediately of lumps in the breast, heavy vaginal bleeding, yellowing of the skin or eyes, or infection of the incision. Women who use Norplant are discouraged from smoking.

Normal results

These hormone contraceptive methods normally result in a success rate of 99%.



"Depo Provera." Planned Parenthood of Western Washington.
"Is Depo-Provera For You?" Planned Parenthood Federation of America, Inc. 〈〉.
"Lunelle." Food and Drug Administration (FDA) Page.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.


trademark for a preparation of the contraceptivelevonorgestrel in the form of an implant that can be inserted beneath a woman's skin.
Insertion of Norplant capsules beneath the skin. From Nichols and Zwelling, 1997.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


An implantable contraceptive system that prevents pregnancy by inhibiting ovulation and thickening the cervical mucus.
Adverse effects
Dysmenorrhea, headache, nervousness, nausea, vertigo, increased size of ovaries and fallopian tubes, dermatitis, acne, weight gain, breast tenderness, hirsutism.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Levonorgestrel Gynecology An implantable contraceptive that prevents pregnancy by inhibiting ovulation and thickening the cervical mucus Adverse effects Dysmenorrhea, headache, nervousness, nausea, vertigo, ↑ size of ovaries and fallopian tubes, dermatitis, acne, weight gain, breast tenderness, hirsutism. See Contraceptive.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


A brand name for a now-withdrawn implantable long-term, reversible contraceptive containing LEVONORGESTREL. Some women may have Norplant in situ until the year 2005. Special precautions are necessary for their removal.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Long-acting contraceptives (LACM) with the implant (Jadelle) and the intrauterine device (IUD) were the most prescribed during this campaign because of the importance they were given during the individual counseling sessions.
Jadelle Levonorgestrel Rod Implants: A Summary of Scientific Data and Lessons Learned from Programmatic Experience.
It is not unusual for women in Kinshasa to refer to specific contraceptive methods by the brand name of the most widely used product (e.g., Jadelle for the implant, Prudence for male condoms or Confiance for the monthly pill).
Along with USAID, UNFPA and other international organisations, the hosts announced a $2.6 billion family planning strategy, 'FP 2020', to get 120 million more girls and women in the poorest countries to use 'voluntary family planning' by 2020.The strategy relies heavily on the mass promotion of long acting hormonal injectable and implantable contraceptives, in particular Depo-Provera, Implanon and Norplant II or Jadelle (produced by pharmaceutical giants Pfizer, Merck and Bayer respectively) all of which have faced sustained opposition from reproductive health activists, who argue that rather than giving poor women in the Global South much needed access to safe contraception they can control, these approaches potentially further undermine women's health and control over their bodies.
There are other methods such as Foaming pills, Jadelle, Implanon, Sino-implants, LAM, IUD, Norigynon, Depo, Bilateral Tubal Ligation, Minipills, Emergency Contraceptive, Micro-N, Female Sterilization, Postinor 2, Micro-G, Ovrette, Lo-Fem, Levonorgestrel Intrauterine System and Micro-lut.
Karachi -- With the support of Bayer HealthCare, DKT Pakistan is proud to add Jadelle, a long term contraceptive, to their extensive portfolio.
It said that with the support of Bayer HealthCare, DKT Pakistan is 'proud to add Jadelle, a long term contraceptive, to their extensive portfolio.
Through this agreement, Bayer HealthCare is providing its long-acting, reversible contraceptive implant, Jadelle, to millions of women in developing countries over the next six years, at a more than 50% discount--at US$8.50 per unit, compared to the standard retail price of US $18.
In September 2012, USAID announced that it was providing a long term contraceptive implant "Jadelle" to women in the poorest countries in the world.
The partnership is with Bayer HealthCare, the maker of the Jadelle progestogen implants, and will benefit some 27 million women.
The long-acting Jadelle implants are small removable rods which are inserted just below the skin in the arm.