SMAD2

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SMAD2

A gene on chromosome 18q21.1 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD2 mediates the signal of transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes—e.g., cell proliferation, apoptosis and differentiation. In response to the binding of TGF-beta, SMAD2 is phosphorylated and dissociated from the SMAD anchor for receptor activation (SARA) protein and forms a complex with SMAD4, resulting in transcription regulation.
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Or I see him setting off to church, for he was a great 'stoop' of the Auld Licht kirk, and his mouth is very firm now as if there were a case of discipline to face, but on his way home he is bowed with pity.
She was her grandfather's companion, and thus he wrote of her death, this stern, self-educated Auld Licht with the chapped hands:-