MYOC

(redirected from JOAG)
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MYOC

A gene on chromosome 1q23-q24 that encodes myocilin, a protein thought to play a role in cytoskeletal function, which is highly expressed in ocular tissues including the trabecular meshwork, which regulates intraocular pressure.

Molecular pathology
MYOC mutations cause hereditary juvenile-onset open-angle glaucoma.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
This prospective controlled clinical trial included 25 eyes of 25 patients recently diagnosed with JOAG and 24 eyes of 24 normal subjects.
Diagnosis criteria for JOAG were optic nerve head changes such as cup-to-disc (C/D) ratio [greater than or equal to]0.3 and localized neuroretinal rim defects, IOP [greater than or equal to]22 mmHg, glaucomatous changes of optic disc and retinal nerve fiber layer in OCT analysis, and visual field defects such as nasal step, Seidel, or arcuate scotoma, and abnormal glaucoma hemifield test in cooperative patients.
Six members of this family were diagnosed as JOAG, and the glaucoma relevant characteristics of each affected member are illustrated in [Table 1].
evaluated mutations in several glaucoma-associated genes in 683 Chinese patients with primary glaucoma and also found c.1456C < T (p.L486F) mutation of MYOC in a sporadic POAG patient, which indicates that the c.1456C<T variants in MYOC are likely to be responsible for the pathogenesis of POAG in this family.[sup][22] The majority of patients in this pedigree were JOAG as the onset of clinical manifestations occurs before the age of 30 years, and the average onset age was 26.3 years.
For their part, Litwak and Joag know they have their work cut out for them--from not forgetting the less-trendy causes, to raising consciousness and funds, to establishing on-the-ground contacts all over the world.
Even in the most repressive regimes, the goal should be to help the artist remain at home with the help of like-minded people in his own society, Joag emphasizes.
WHAT JOAG says is the crux of the findings by the artist group involved with the project and that's what would be on display at the exhibition.
The less frequent juvenile open angle glaucoma (JOAG) usually has a more severe phenotype with an age of onset between 3 and 30 years.
In general, wife's work involvement has been shown to be positively related to frequency of restaurant meals, take-out foods and delivery services, and fast-food usage and negatively related to meal preparation at home (Joag, Gentry, and Hopper, 1985; Nickols and Fox, 1983).
Aesthetic Bind: Phantomata--Nikhil Chopra, Tushar Joag, Sonia Khurana, Tallur L.
Citizen Artist: Forms of Address--CAMP, Shilpa Gupta, Tushar Joag, Jitish Kallat, KM Madhusudan, Pushpamala N., Rashid Rana, RAQS Media Collective, and Gigi Scaria
A Floating Object: The Guild Collection--Series I-2012: Zakkir Hussain, Tushar Joag, Gieve Patel, Sudhir Patwardhan, Prajakta Potnis, Sumedh Rajendran, K.P.