MAPK10

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MAPK10

A gene on chromosome 4q22.1 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK10 is a neuronal-specific form of c-Jun N-terminal kinase, which regulates signalling pathways during neuronal apoptosis.
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Inhibition of ceramide synthase with both FB1 and JNK3 knockout reduced the accumulation of ceramide and decreased the size of brain infarct regions in a cerebral IR model [43].
Miller et al., "[beta]-Arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3," Science, vol.
After transferring, the membranes were blocked with 5% bovine serum albumin (BSA) in TBS with 0.1% Tween-20 for 1 h at 37[degrees]C and then blotted at 4[degrees]C overnight with GAPDH, MyD88, p-p38, p-I[kappa]B, or p-JNK1 + JNK2 + JNK3 primary antibodies.
Emerging evidence indicates that whereas JNK1/2 isoforms promote obesity and insulin resistance which are both linked to hypertriglyceridemia and decreased JNK3 activity may protect from excessive adiposity [124], and further p38 MAPK antagonizes JNK [125].
The mammalian MAPK family consists of ERK, p38, and JNK with each member having several isoforms: ERK1 to ERK8; p38a (MAPK14), p38fi (MAPK11), p38g (MAPK12), and p38S (MAPK13); and JNK1 (MAPK8), JNK2 (MAPK9), and JNK3 (MAPK10).
Pyrrolo-[1, 2-a] imidazoles recently been used as JNK3 inhibitors [1].
The c-Jun NH2-terminal protein kinase (JNKs) is part of the mitogen-activated protein kinase (MAPK) family [1, 2] and is represented in mammals by three genes coding for three isoforms: JNK1, JNK2, and JNK3. JNK1 and JNK2 expression is essentially ubiquitous, while JNK3 presence is restricted to brain and testis [3].
Del Carpio et al., "Three-dimensional quantitative structure-activity relationship (3 DQSAR) and docking studies on (benzothiazole-2-yl) acetonitrile derivatives as c-Jun N-terminal kinase-3 (JNK3) inhibitors," Bioorganic and Medicinal Chemistry Letters, vol.
There are three different isoforms, JNK1, JNK2, and JNK3, in the JNKs family; however, only the Jnk1 and Jnk2 genes can be expressed ubiquitously in all tissues [56, 57].
Akagi et al., "Aberrant tau phosphorylation by glycogen synthase kinase-3[beta] and JNK3 induces oligomeric tau fibrils in COS-7 cells," Journal of Biological Chemistry, vol.
SDF-1[alpha] promotes migration of ECs or EPCs by activating JNK3. eNOS, activated via SDF-1[alpha]/Akt, produces nitric oxide (NO) and nitrosylates MAPK phosphatase 7 (MKP7), suggesting that eNOS and JNK3 contribute to SDF-1[alpha]-dependent migration of ECs or EPCs [98].