MAPK8

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MAPK8

A gene on chromosome 10q11.22 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK8 is activated by various cell stimuli and targets specific transcription factors, mediating immediate early gene expression in response to cell stimuli. MAPK8 activation by TNF-alpha is a requisite for TNF-alpha-induced apoptosis, including that induced by UV light, which may be related to cytochrome C-mediated cell death. MAPK8 plays a key role in T cell proliferation, apoptosis and differentiation.
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References in periodicals archive ?
After finding JNK and TGF-beta pathways to be overactive only in EAC biopsies, they then incubated EAC tumour cells with therapeutic small molecules designed to block the pathways.
Several studies have demonstrated the involvement of ERK1/2, P38, and JNK in inflammation and cell apoptosis.
With the acquisition of JNK, Uphold is enhancing its compliance and regulatory policies and practices.
The phosphorylation of Erk, JNK and p38 could be up regulated when facing the stimulation of LPS.18 But how MAPKs regulate during the LPS stimulation in skin fibroblast cells needs to be investigated.
Okada et al., "Targeting JNK for therapeutic depletion of stem-like glioblastoma cells," Scientific Reports, vol.
Nonspecific binding was blocked with phosphate-buffered saline (PBS) containing 0.1% Tween 20 (PBST) and 5% nonfat milk (dissolved with PBS) for 1 h, and the membranes were incubated overnight at 4[degrees]C with the following primary antibodies and dilutions: [beta]-actin (1: 1000) LC3 (1: 1000), Beclin 1 (1: 500), Bcl-2 (1: 1000), Bax (1:500), caspase-3 (1:500), JNK (1:1000), phospho-JNK (1: 500), and TRAF2 (1: 1000).
As JNK is a downstream signal of TLR4, in the present study we next investigated the effect of high glucose on JNK phosphorylation.
JNK activation, in fact, induces neuronal death in a wide range of pathological conditions, such as NMDA-induced excitotoxicity, ischemic stroke [9-11], and traumatic brain injury [12]; JNK activation has been also associated to many neurodegenerative disorders like Alzheimer [13-18], Huntington's [19], and Parkinson's disease [20, 21], but also psychiatric disorders and intellectual disabilities involving synaptic structure anomalies [22].
Wdr62 is a microtubule-associated scaffold protein that is regulated by tiered c-Jun N-terminal kinase (JNK) signalling modules [4, 5].