KDM6B

(redirected from JMJD3)

KDM6B

A gene on chromosome 17p13.1 that encodes lysine-specific demethylase 6B, which demethylates histone H3 and is involved in regulating posterior development by regulating HOX gene expression. KDM6B participates in inflammation by regulating gene expression and macrophage differentiation.
References in periodicals archive ?
The histone demethylases JMJD3 produce diverse outputs of biological function, depending on the action of their transcriptional complexes.
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4AARF locus in response to oncogene- and stress-induced senescence," Genes & Development, vol.
21] demonstrated that RANKL stimulation upregulated the jumonji domain-containing 3 (jmjdy) gene, and short hairpin RNAs of jmjd3 gene diminished RANKL-induced osteoclast differentiation, suggesting that JMJD3, a H3K27 demethylase, plays an important role in osteoclast differentiation.