KDM6B

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KDM6B

A gene on chromosome 17p13.1 that encodes lysine-specific demethylase 6B, which demethylates histone H3 and is involved in regulating posterior development by regulating HOX gene expression. KDM6B participates in inflammation by regulating gene expression and macrophage differentiation.
References in periodicals archive ?
Shen et al., "JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity," Oncotarget, vol.
Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.
Ellert-Miklaszewska et al., "The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia," Journal of Molecular Medicine, vol.
Christensen et al., "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development," Nature, vol.
[21] demonstrated that RANKL stimulation upregulated the jumonji domain-containing 3 (jmjdy) gene, and short hairpin RNAs of jmjd3 gene diminished RANKL-induced osteoclast differentiation, suggesting that JMJD3, a H3K27 demethylase, plays an important role in osteoclast differentiation.
Wang and his group identified a protein encoded by the gene Jmjd3 (also called KDM6B) as a roadblock in the stem cell conversion process.
Alternatively activated (M2) macrophages are formed in response to Th2 cytokines (IL-4, IL-10, IL-13, M-CSF, CCL2, CCL5, CCL22, and HIF-1a) and are characterized by the expression of JMJD3, arginase-1, YM, and FIZZ1 genes and secretion of IL-4, IL-10, and IL-13 upon activation, an expression/secretion profile more in tune with tissue remodeling activities.
Soma et al., "Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells," Development, vol.
The histone demethylases JMJD3 produce diverse outputs of biological function, depending on the action of their transcriptional complexes.
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.
Tang et al., "Aberrant JMJD3 Expression Upregulates Slug to Promote Migration, Invasion, and Stem Cell-Like Behaviors in Hepatocellular Carcinoma," Cancer Research, vol.