H3K9 is demethylated by the KDM1 family (LSD1), the KDM3 family (JMJD1A and JMJD1B), and the KDM4 family (JMJD2A, JMJD2B, JMJD2C, and JMJD2D) as well as JMJD1C, PHF8, and JHDM1D.
H3K36 is demethylated by the KDM2 family (FBXL10 and FBXL11), the KDM4 family (JMJD2A, JMJD2B, and JMJD2C), and NO66.
Ng, "Jmjd1a and Jmjd2c
histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells," Genes & Development, vol.
Jmjd2a and Jmjd2c can modify the expression of genes controlled by the nuclear receptor PPARg [101,102].
Vargas, "Regulation of adipogenesis by nuclear receptor PPAR[gamma] is modulated by the histone demethylase JMJD2C," Genetics and Molecular Biology, vol.
"The protein JMJD2C is the key that opens up a whole suite of genes needed for tumors to grow and metastasize, so it represents a potential target for cancer drug development," he said.
JMJD2C is both an important piece of the puzzle of how tumors metastasize, and a potential target for anti-cancer therapy," said Luo.
Littleton, CO, March 20, 2011 --(PR.com)-- Novus Biologicals announced today the release of three new rabbit polyclonal antibodies to important histone demethylase proteins: JMJD2C
(Catalog# NBP1-49600), JMJD1A (Catalog# NBP1-49601), and JMJD2A (Catalog# NBP1-49602).