KDM4B

(redirected from JMJD2B)

KDM4B

A gene on chromosome 19p13.3 that encodes lysine-specific demethylase 4B, which demethylates histone H3; it generates formaldehyde and succinate and acts as a transcription repressor.
References in periodicals archive ?
Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.
H3K9 is demethylated by the KDM1 family (LSD1), the KDM3 family (JMJD1A and JMJD1B), and the KDM4 family (JMJD2A, JMJD2B, JMJD2C, and JMJD2D) as well as JMJD1C, PHF8, and JHDM1D.
Jmjd2b antagonizes H3K9 tri-methylation at pericentric heterochromatin in mammalian cells.