contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI.
H3K9 is demethylated by the KDM1 family (LSD1), the KDM3 family (JMJD1A and JMJD1B), and the KDM4 family (JMJD2A, JMJD2B, JMJD2C, and JMJD2D) as well as JMJD1C, PHF8, and JHDM1D.
H3K36 is demethylated by the KDM2 family (FBXL10 and FBXL11), the KDM4 family (JMJD2A, JMJD2B, and JMJD2C), and NO66.
Xiaolin et al., "Histone demethylase JMJD2A
inhibition attenuates neointimal hyperplasia in the carotid arteries of balloon-injured diabetic rats via transcriptional silencing: inflammatory gene expression in vascular smooth muscle cells," Cellular Physiology and Biochemistry, vol.
and Jmjd2c can modify the expression of genes controlled by the nuclear receptor PPARg [101,102].
[sup] Latest SIRT2 has been identified as an anti-oncogenic protein in nonsmall cell lung cancer by targeting JMJD2A. [sup] SIRT6 plays an important role in preventing tumorigenesis.
SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A. Biol Chem 2015 [Epub ahead of print].
In addition, we observed down-regulation of DNA methyltransferase 1 (Dnmt1) and suppressor of variegation 3-9 homolog 1, a histone lysine methyltransferase (Suv39h1), and up-regulation of the histone demethylase Jumonji domain 2 (Jmjd2a), proteins responsible for the accurate maintenance of the epigenetic marks.
(2006) to assess the status of histone H3 lysine 9 (H3K9), histone H3 lysine 27 (H3K27), and histone H4 lysine 20 (H4K20) trimethylation, as well as protein levels of DNA methyltransferase 1 (Dnmtl), histone lysine methyltransferases Suv39hl and Suv4-20hl, histone demethylase Jumonji domain 2 (Jmjd2a), and [beta]-actin.
Effect of BD exposure on the levels of Dnmtl, Suv39hl, Suv4-20bl, and Jmjd2a proteins.
Littleton, CO, March 20, 2011 --(PR.com)-- Novus Biologicals announced today the release of three new rabbit polyclonal antibodies to important histone demethylase proteins: JMJD2C (Catalog# NBP1-49600), JMJD1A (Catalog# NBP1-49601), and JMJD2A (Catalog# NBP1-49602).
JMJD2C and JMJD2A are members of the JHDM3 histone demethylase family.