KDM4A

(redirected from JMJD2)

KDM4A

A gene on chromosome 1p34.1 that encodes lysine-specific demethylase 4A, which demethylates histone H3; it generates formaldehyde and succinate and acts as a transcription repressor.
References in periodicals archive ?
Radzisheuskaya et al., "Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development," EMBO Journal, vol.
Lysine specific demethylase 1 (LSD1) and Jumonji domain containing proteins (JMJD1A, JMJD2, JMJD3/UTX, and JARID1B) are two major histone demethylases (HDMTs) that have been identified to erase methylation from histone proteins in HCC [34].