H3K9 is demethylated by the KDM1 family (LSD1), the KDM3 family (JMJD1A
and JMJD1B), and the KDM4 family (JMJD2A, JMJD2B, JMJD2C, and JMJD2D) as well as JMJD1C, PHF8, and JHDM1D.
and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells," Genes & Development, vol.
Lysine specific demethylase 1 (LSD1) and Jumonji domain containing proteins (JMJD1A, JMJD2, JMJD3/UTX, and JARID1B) are two major histone demethylases (HDMTs) that have been identified to erase methylation from histone proteins in HCC .
JMJD1A is an important regulator of hypoxia-inducible transcription factor and also stimulates tumour growth.
Son et al., "The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia," Biochemical and Biophysical Research Communications, vol.
Matsumura et al., "JMJD1A
is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis," Nature Communications, vol.
Wang et al., "Upregulation of miR-155 in nasopharyngeal carcinoma is partly driven by LMP1 and LMP2A and downregulates a negative prognostic marker JMJD1A
," PLoS ONE, vol.
Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.
Littleton, CO, March 20, 2011 --(PR.com)-- Novus Biologicals announced today the release of three new rabbit polyclonal antibodies to important histone demethylase proteins: JMJD2C (Catalog# NBP1-49600), JMJD1A (Catalog# NBP1-49601), and JMJD2A (Catalog# NBP1-49602).
JMJD1A is a member of the JHDM2 histone demethylase family, and preferentially demethylates mono- and dimethylated H3 'Lys-9' residue but has weak or no activity on trimethylated H3 'Lys-9'.