KDM3A

(redirected from JMJD1A)

KDM3A

A gene on chromosome 2p11.2 that encodes lysine-specific demethylase 3A, which demethylates histone H3. KDM3A is involved in hormone-dependent transcriptional activation, spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 (which are required for packaging), and condensation of sperm chromatin. It is also involved in obesity resistance by regulating metabolic genes (e.g., PPARA and UCP1).
References in periodicals archive ?
Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.
JMJD1A is a member of the JHDM2 histone demethylase family, and preferentially demethylates mono- and dimethylated H3 'Lys-9' residue but has weak or no activity on trimethylated H3 'Lys-9'.