juvenile chronic arthritis

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ju·ve·nile ar·thri·tis

, juvenile rheumatoid arthritis
chronic arthritis beginning in childhood, most cases of which are pauciarticular, that is, affecting few joints. Several patterns of illness have been identified. In one subset, primarily affecting girls, iritis is common and antinuclear antibody is usually present; another subset, primarily affecting boys, frequently includes spinal arthritis resembling ankylosing spondylitis. Some cases are true rheumatoid arthritis beginning in childhood and characterized by the presence of rheumatoid factor and destructive deforming joint changes, often going into remission at puberty.
See also: Still disease.

juvenile chronic arthritis

; JCA; juvenile idiopathic arthritis; JIA; Still's disease group of inflammatory, immune-mediated arthropathies (i.e. systemic arthritis, oligoarthritis, polyarthritis [rheumatoid factor-negative/RF-ve, antinuclear factor-positive/ANF+ve, or RF-ve, ANF-ve, or RF+ve], juvenile psoriatic arthritis [RF-ve], enthesis-related arthritis, other arthritides) affecting children aged <16 years (may present at <4 years of age); girls affected more than boys; indicated by presence of inflammatory arthropathy (of one or more joints for longer than 6 weeks); presents as chronic, idiopathic, monoarthritis (e.g. hip, knee, ankle, subtalar joint); recruitment of other joints occurs in polyarticular form; inflammation may involve ossification centres, leading to limb length discrepancy, hallux abductovalgus, pes cavus, pes planus and altered plantar pressures; condition is managed by drug therapies and ongoing provision of in-shoe orthoses
References in periodicals archive ?
Unlike adult RA, in JIA the clinician is treating a growing patient.
Also, eight children with JIA (six with oligoarthritis and two with RF negative poliarthritis) were followed-up prospectively.
Low concentration of CS, recorded in serum of JIA patients with untreated arthroplasty, was negatively statistically significantly correlated with the concentrations of laboratory inflammatory markers, that is, CRP and ESR.
For the purpose of classification, JIA is divided into 7 heterogeneous subtypes with specific clinical and pathophysiological characteristics (Table 2).
As local JIA data is scarce, it was a frequent presenting complaint in paediatric outpatient department (OPD).
AbbVie Pharmaceutical Development vice-president, Scott Brun, stated that the company is happy that children between the ages of two and four living with polyarticular JIA will now have Humira as an additional treatment option.
JIA outcome measures have been validated and are now widely used in clinical trials, including the ACR Pedi 30/50/70.
As an inflammatory disease, JIA is the most common form of persistent arthritis in children that affects somewhere between 16-150 of every 100,000 children and is characterized with morning stiffness, swelling of the affected joint(s), pain, limping and nonspecific flu-like symptoms with respect to clinical type (12,13).
In an open-label study, the response rate was 73% (11 of 15) for children with systemic juvenile idiopathic arthritis (JIA), compared with 67% (6 of 9) for children with pauciarticular and 52% (29 of 56) for children with polyarticular JIA.