KDM3A

(redirected from JHDM2A)

KDM3A

A gene on chromosome 2p11.2 that encodes lysine-specific demethylase 3A, which demethylates histone H3. KDM3A is involved in hormone-dependent transcriptional activation, spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 (which are required for packaging), and condensation of sperm chromatin. It is also involved in obesity resistance by regulating metabolic genes (e.g., PPARA and UCP1).
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References in periodicals archive ?
JHDM2A expression is increased, whereas HDAC2, HDAC7, and SUV39H2 expression is decreased in SSc B cells.
Knockdown of Jhdm2a gene, the H3K9me2 demethylase, has been reported to lead to obesity and hyperlipidemia, implying an important role of histone modifications in diabetes [60].
Genetic knockout of the Jumonji C-domain containing protein (Jhdm2a), a H3K9 demethylase, is able to increase mice susceptibility to obesity by abnormal fat deposition and hyperlipidaemia, likely due to PPAR[alpha] expression decrease in skeletal muscles and brown fat [131].
JHDM2A, a JmjC-containing H3K9 demetfiylase, facilitates transcription activation by androgen receptor.