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Infection with JCV is required for the development of progressive multifocal leukoencephalopathy (PML), an infrequent but serious brain infection seen in some patients treated with TYSABRI.
The epidemiology and clinical spectrum of LACV are well described (3), whereas less is known about JCV.
The Tysabri-STRATIFY JCV example reflects the value of immunodiagnostics in connection with clinical administration of immunemodulating continued on page 74 therapies.
Untreated urine (5 [micro]L; diluted 1:10 in distilled water) was examined with a quantitative TagMan PCR assay that detects BKV as well as JCV.
Natalizumab should be avoided in patients with positive JCV serology.
001), but when BKV was found coinfecting with JCV, 128-1 prevailed in the urine, blood, and renal biopsy samples (P < .
Because of suspicion that cases were being missed by an assay in use at the time in Minnesota, which had relatively poor sensitivity for detecting Jamestown Canyon virus, an enzyme immunoassay specific to JCV was put into use in 2014 to test serum and cerebrospinal fluid specimens submitted for other arboviral testing.
JCV is common, perhaps infecting as much as 90 percent of the adult population--a factor that can complicate virus-cancer investigations.
The large T antigens of JCV and BKV share many functional domains with, and have high homology to, SV40 Tag.
Invasion of myelin-producing oligodendrocytes by the JCV causes foci of demyelination.
JCV is a human polyomavirus that is extremely common, affecting up to 90% of the general population.
Nevertheless, of those patients who have developed PML, all 20 who have been assessed (thus far) have had antibody evidence of JCV virus (JCV) infection prior the start of natalizumab.
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