PCR detection of JC virus
DNA in the brain tissue of a 9-year-old child with pleomorphic xanthoastrocytoma.
as a marker of human migration to the Americas.
Although the JC virus
can be detected by PCR in CSF, the definitive diagnosis should be made by detecting JC virus
DNA or antigens in a brain biopsy.
Polyomavirus belongs to Papovaviridae, among which, BC virus (BCV) and JC virus
(JCV) can induce diseases.1,2 It has been reported that,3 patients who undergo renal transplant usually have weak immune function, which improves possibility of polyomavirus infection.
Possible mechanisms include HIV's effect on immune cell trafficking or permeability of the blood brain barrier; intrinsic damage caused by HIV and possible synergism between HIV and JC virus
in co-infected cells have also been proposed.
A serological investigation of BK virus and JC virus
infections in recipients of renal allografts.
Knowles, "Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus
(JCV)," Advances in Experimental Medicine and Biology, vol.
HIV-associated neuro-cognitive disorder EBV: primary CNS lym-phoma JC virus
: PML [not equal to] Prions: spongiform ence- phalopathy Spinal Acute viral HIV-1 vacuolar cord myelitis myelopathy ADEM * HTLV-1 myelopathy * Acute disseminated encephalomyelitis [dagger] Subacute sclerosing panencephalitis [not equal to] Progressive multifocal leucoencephalopathy.
A new assay for serum antibodies to JC virus
(indicating past exposure) may prove to be a guide to PML risk.
BK virus (BKV), together with JC virus
and simian virus 40, are members of the genus polyomavirus (Polyomaviridae family).
* If confusion is prominent and/or the patient has a headache and/or fever, it is prudent to request polymerase chain reaction (PCR) testing of the cerebrospinal fluid for cytomegalovirus, herpes simplex virus, Epstein-Barr virus and JC virus