JC virus


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Related to JC virus: BK virus

JC vi·rus

a human polyomavirus, family Papovaviridae, of worldwide distribution that produces infections that are usually subclinical in immunocompetent people, but is associated with progressive multifocal leukoencephalopathy in the immunosuppressed.
[initials of patient from whom first isolated]

JC vi·rus

(vīrŭs)
Human polyomavirus of worldwide distribution that produces infections that are usually subclinical in immunocompetent people, but is associated with progressive multifocal leukoencephalopathy in the immunosuppressed.

JC virus

A DNA papovavirus that causes progressive multifocal leukoencephalopathy in immunosuppressed patients. It is carried asymptomatically by a large percentage of the population.
See also: virus
References in periodicals archive ?
PCR detection of JC virus DNA in brain tissue from patients with and without progressive multifocal leukoencephalopathy.
4] In South Africa, a study that examined the JC virus in the cerebrospinal fluid (CSF) of patients with suspected PML showed JC virus type 3 in 3 patients, and type 7 and 2 in 1 patient each, confirming that the virus occurs in South African patients.
Although BK and JC viruses are latent in the kidney and may become reactivated in immunosuppressed individuals, only JC virus has been shown to infect the central nervous system.
PML is caused by activation of JC virus, a human polyomavirus, which is latent in most healthy adults (N.
Imatinib, the active ingredient in the Company's lead product IkT-001Pro, is a host-directed protein kinase inhibitor that disrupts the ability of JC virus to reproduce in the patient.
WU polyomavirus (WUPyV) (1) and K1 polyomavirus (KIPyV) (2) are newly described human polyomaviruses most closely related to JC virus (JCV) and BK virus (BKV).
BOSTON -- JC virus, a human polyomavirus known to promote neurologic disease, may lurk in a quarter of all kidney transplant patients suspected of harboring a BK polyomavirus infection, said Pradip Manna, Ph.
Host-Targeted Antiviral Validated to Block Patient-Derived JC Virus -
To the Editor: Before 2007, two human polyomaviruses were known to infect humans: BK virus and JC virus (1,2).
Although BK virus, JC virus, and simian virus 40 are tumorigenic in experimental animals and can transform mammalian cells in vitro, no convincing epidemiologic evidence exists for their role in human cancers.