PCR detection of JC virus
DNA in brain tissue from patients with and without progressive multifocal leukoencephalopathy.
4] In South Africa, a study that examined the JC virus
in the cerebrospinal fluid (CSF) of patients with suspected PML showed JC virus
type 3 in 3 patients, and type 7 and 2 in 1 patient each, confirming that the virus occurs in South African patients.
BK virus and a new type of JC virus
excreted by HIV-1 positive patients in rural Tanzania.
Although BK and JC viruses
are latent in the kidney and may become reactivated in immunosuppressed individuals, only JC virus
has been shown to infect the central nervous system.
in experimental and clinical brain tumors.
PML is caused by activation of JC virus
, a human polyomavirus, which is latent in most healthy adults (N.
Imatinib, the active ingredient in the Company's lead product IkT-001Pro, is a host-directed protein kinase inhibitor that disrupts the ability of JC virus
to reproduce in the patient.
WU polyomavirus (WUPyV) (1) and K1 polyomavirus (KIPyV) (2) are newly described human polyomaviruses most closely related to JC virus
(JCV) and BK virus (BKV).
BOSTON -- JC virus
, a human polyomavirus known to promote neurologic disease, may lurk in a quarter of all kidney transplant patients suspected of harboring a BK polyomavirus infection, said Pradip Manna, Ph.
Host-Targeted Antiviral Validated to Block Patient-Derived JC Virus
To the Editor: Before 2007, two human polyomaviruses were known to infect humans: BK virus and JC virus
Although BK virus, JC virus
, and simian virus 40 are tumorigenic in experimental animals and can transform mammalian cells in vitro, no convincing epidemiologic evidence exists for their role in human cancers.