JC virus

(redirected from JC polyomavirus)

JC vi·rus

a human polyomavirus, family Papovaviridae, of worldwide distribution that produces infections that are usually subclinical in immunocompetent people, but is associated with progressive multifocal leukoencephalopathy in the immunosuppressed.
[initials of patient from whom first isolated]

JC vi·rus

(vīrŭs)
Human polyomavirus of worldwide distribution that produces infections that are usually subclinical in immunocompetent people, but is associated with progressive multifocal leukoencephalopathy in the immunosuppressed.

JC virus

A DNA papovavirus that causes progressive multifocal leukoencephalopathy in immunosuppressed patients. It is carried asymptomatically by a large percentage of the population.
See also: virus
References in periodicals archive ?
(Ashley et al., 2011; Abbing et al., 2004) To deliver Paclitaxel, a JC polyomavirus VLP system was also synthesized which encapsulates the coupled drug with cyclodextrins as hydrophobic pockets through disulfide bonds inside the VLPs and has capable of glutathione (GSH)- triggered release of drug molecules.
Results of PCRs for AFB, cytomegalovirus, and JC polyomavirus were negative.
On culturing JC polyomavirus, deletions in the viral genome commonly arise (37), and these deletions often involve the T antigen (38).
(119,121) Many of the available antibodies react with epitopes common to SV-40, BK polyomavirus, and JC polyomavirus and thus can be applied to diagnosis of nephropathy (most often BK), cystitis (BK and some JC), and progressive multifocal leukoencephalopathy (generally JC).
Gallia et al., "Cooperative action of cellular proteins YB-1 and Pura with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element," Proceedings of the National Academy of Sciences of the United States of America, vol.
Infection with BK polyomavirus (BKPyV) or JC polyomavirus causes substantial illness and death in immunocompromised populations, including transplant recipients and HIV patients (1).
Gran, "Atypical progressive multifocal leukoencephalopathy associated with an unusual JC polyomavirus mutation," Archives of Neurology, vol.
There are 5 human polyomaviruses: BK polyomavirus, JC polyomavirus, KI (Karolinska Institute) polyomavirus, WU (Washington University) polyomavirus, and Merkel cell virus.
JC polyomavirus was also detected in the urine but not in the blood.
Khalili, "Transcriptional regulation of human JC polyomavirus promoters by cellular proteins YB-1 and Pur a in glial cells," Journal of Virology, vol.
BK polyomavirus (BKPyV) has been associated with nephropathy in renal transplant recipients and JC polyomavirus (JCPyV) with progressive multifocal leukoencephalopathy in immunocompromised persons (2,3).