JC virus

(redirected from JC polyomavirus)

JC vi·rus

a human polyomavirus, family Papovaviridae, of worldwide distribution that produces infections that are usually subclinical in immunocompetent people, but is associated with progressive multifocal leukoencephalopathy in the immunosuppressed.

[initials of patient from whom first isolated]

JC vi·rus

(vīrŭs)

Human polyomavirus of worldwide distribution that produces infections that are usually subclinical in immunocompetent people, but is associated with progressive multifocal leukoencephalopathy in the immunosuppressed.

JC virus

A DNA papovavirus that causes progressive multifocal leukoencephalopathy in immunosuppressed patients. It is carried asymptomatically by a large percentage of the population.

See also: virus

References in periodicals archive ?

(Ashley et al., 2011; Abbing et al., 2004) To deliver Paclitaxel, a JC polyomavirus VLP system was also synthesized which encapsulates the coupled drug with cyclodextrins as hydrophobic pockets through disulfide bonds inside the VLPs and has capable of glutathione (GSH)- triggered release of drug molecules.

Targeted drug delivery and vaccinology approaches using virus-like particles for cancer

Results of PCRs for AFB, cytomegalovirus, and JC polyomavirus were negative.

Central nervous system brucellosis granuloma and white matter disease in immunocompromised patient

On culturing JC polyomavirus, deletions in the viral genome commonly arise (37), and these deletions often involve the T antigen (38).

Quantification of BK Virus Standards by Quantitative Real-Time PCR and Droplet Digital PCR Is Confounded by Multiple Virus Populations in the WHO BKV International Standard

The human BK polyomavirus (BKPyV) and JC polyomavirus (JCPyV) are ubiquitous pathogens [1].

Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus Extracts Effectively Inhibit BK Virus and JC Virus Infection of Host Cells

(119,121) Many of the available antibodies react with epitopes common to SV-40, BK polyomavirus, and JC polyomavirus and thus can be applied to diagnosis of nephropathy (most often BK), cystitis (BK and some JC), and progressive multifocal leukoencephalopathy (generally JC).

Practical Applications in Immunohistochemistry: Evaluation of Rejection and Infection in Organ Transplantation

Gallia et al., "Cooperative action of cellular proteins YB-1 and Pura with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element," Proceedings of the National Academy of Sciences of the United States of America, vol.

Polyomavirus JC in the context of immunosuppression: a series of adaptive, DNA replication-driven recombination events in the development of progressive multifocal leukoencephalopathy

Infection with BK polyomavirus (BKPyV) or JC polyomavirus causes substantial illness and death in immunocompromised populations, including transplant recipients and HIV patients (1).

Multiorgan WU polyomavirus infection in bone marrow transplant recipient

Gran, "Atypical progressive multifocal leukoencephalopathy associated with an unusual JC polyomavirus mutation," Archives of Neurology, vol.

Human polyomavirus reactivation: disease pathogenesis and treatment approaches

There are 5 human polyomaviruses: BK polyomavirus, JC polyomavirus, KI (Karolinska Institute) polyomavirus, WU (Washington University) polyomavirus, and Merkel cell virus.

Merkel cell carcinoma of the genitourinary tract

JC polyomavirus was also detected in the urine but not in the blood.

WU polyomavirus in respiratory epithelial cells from lung transplant patient with job syndrome

Khalili, "Transcriptional regulation of human JC polyomavirus promoters by cellular proteins YB-1 and Pur a in glial cells," Journal of Virology, vol.

New insights on human polyomavirus JC and pathogenesis of progressive multifocal leukoencephalopathy

BK polyomavirus (BKPyV) has been associated with nephropathy in renal transplant recipients and JC polyomavirus (JCPyV) with progressive multifocal leukoencephalopathy in immunocompromised persons (2,3).