JARID2

JARID2

A gene on chromosome 6p24-p23 that encodes an ortholog of the mouse jumonji gene, which encodes a nuclear protein essential for mouse embryogenesis. JARID2 is a regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion and haematopoiesis, modulating histone methyltransferase activity and recruiting histone methyltransferase complexes to their target genes; it downregulates cell proliferation signalling pathways. During embryogenesis, it is primarily expressed in neurons, especially in dorsal root ganglion cells. It interacts with GATA4, NKX2-5, RB1, SUZ12 and ZNF496.
References in periodicals archive ?
This complex included Ezh2, Jarid2, Mtf2, Nanog, Pou5f1, Sall4, Smarca4, Sox2, Suz12, and Tcf3.
The catalytic activity of EZH2 requires other PRC2 components including embryonic ectoderm development (EED), suppressor of zeste 12 (SUZ12), retinoblastoma-binding protein 4 (RBBP4), adipocyte enhancer binding protein 2 (AEBP2), and JARID2. EZH2 has a conserved feature of histone lysine methyltransferase C-terminal SET-domain whose function is to add a methyl group to lysine side chains of substrate proteins.
Escamilla-Del-Arenal et al., "Jarid2 is implicated in the initial Xist-induced targeting of PRC2 to the inactive X chromosome," Molecular Cell, vol.
H3K4 is demethylated by the KDM1 family (LSD1 and AOF1), the KDM2 family (FBXL10), and the KDM5 family (JARID1A, JARID1B, JARID1C, and JARID1D) as well as JARID2 and NO66.
MiR-155 acts as a prohypertrophic factor by abolishing the expression of Mef2A and Jarid2 in cardiomyocytes and inhibition of miR-155 improves the cardiac function from hypertrophy induced progressive heart failure [33].
Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart.
Shaw, "Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program," Journal of Thoracic and Cardiovascular Surgery, vol.
The protein called Jarid2 maintains a delicate balancing act - one that both recruits other regulatory proteins to genes important in differentiation and also modulates their activity to keep them in a state of ongoing readiness.
The immunomodulatory and regenerative properties of human DP-MSCs are reflected in the expression of embryonic stem cell markers like SKIL, MEIS1, and JARID2. These markers, as well as cell proliferation markers, were shown not to be influenced by the total number of in vitro passages.
Walfridsson et al., "JARID2 regulates binding ofthe Polycomb repressive complex 2 to target genes in ES cells," Nature, vol.
MEG3 recruits PRC2 to chromatin via interaction with jumonji family, ARID domain-containing protein 2 (JARID2) [71].
The pathway gene expression modulation is similar for hGMSCs and hPDLSCs displaying the overexpression of transcripts such as FOXC1, MEIS1, STAT3, and ZFHX3 while hDPSCs reveal a unique gene signature with the overexpression of only three transcripts (GBX2, JARID2, and SKIL).