SOCS1

(redirected from JAK-binding protein)

SOCS1

A gene on chromosome 16p13.13 that encodes a member of the suppressor of cytokine-signalling—i.e., STAT-induced STAT inhibitor—family, which are cytokine-inducible negative regulators of cytokine signalling. SOCS1 expression is induced by cytokines (e.g., IL2, IL3, erythropoietin, CSF2/GM-CSF and interferon-gamma), and it provides a negative feedback loop to attenuate cytokine signalling.
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References in periodicals archive ?
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop.
Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: role in apoptosis induction and radiosensitization in head and neck tumor cells
Sakamoto et al., "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop," The EMBO Journal, vol.
The role of suppressors of cytokine signalling in human neoplasms

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