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heterogeneity: desmin-negative Ito cells
in normal rat liver," Hepatology, vol.
During liver fibrogenesis, hepatic stellate cells or Ito cells are activated and differentiate into myofibroblasts (8).
Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis.
Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis.
Suzuki et al., "Intravital and electron microscopic observation of Ito cells
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Glial fibrillary acidic protein - a cell type specific marker for Ito cells in vivo and in vitro.
Novel insights into the biology and physiology of the Ito cell. Clinical Pharmacology and Therapeutics 66, 387-412.
Physiopathological mechanisms implicated in the progression of hepatic fibrosis during chronic HCV infection are multiple, but HSC (perisinusoidal cells, Ito cells or fat-storing cells) activation is known to play a key role in the pathogenesis of hepatic fibrosis [30,31].
Distribution of Ito cells in experimental hepatic fibrosis Liver 1988;8:48-52.
Light microscopic changes consisted of nuclear displacement from the normal central cytoplasmic location in parenchymal cells, mononuclear cell infiltrations (mainly portally and as lipid granulomas), mild bile duct proliferation accompanied by fibrosis, and fat accumulation in hepatocytes and pluripotent Ito cells. Lipid accumulation in Ito ceils and bile duct hyperplasia accompanied by portal fibrosis were correlated to age, whereas no changes were associated with either sex or season (summer vs.
* Visible Ito cells: average number in five fields at 20x magnification
* Ito cells: mild (< 10), moderate (10 to < 50), severe (50-200).