itai-itai disease

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i·tai-·i·tai dis·ease

a form of cadmium poisoning described in some Japanese people, characterized by renal tubular dysfunction, osteomalacia, pseudofractures, and anemia, caused by ingestion of contaminated shellfish or other sources containing cadmium.
Farlex Partner Medical Dictionary © Farlex 2012
A form of renal osteodystrophy—osteomalacia with marked bone pain and painful fractures—described in multiparous Japanese women due to cadmium accumulation in bone, caused by industrial pollutants
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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The osteomalacia observed in Itai-itai disease would have occurred as a consequence of Cd-induced damage to the renal cortex, which probably hampered the occurrence of the second hydroxylation of vitamin D in the affected cells [28].
They also pose a number of health hazards to humans such as Cd intake can lead to itai-itai disease, mercury accumulation may cause minimata disease and As intake through contaminated drinking water can cause poisoning [5].
Itai-Itai disease, which affected thousands of people in Japan and even many lead to death, was caused by Cd (Baby et al., 2010).
In the mid of 1950s a disease named itai-itai was reported in Japan.
In contaminated regions of Japan the chronic exposure of humans to Cd resulted in the occurrence of an epidemic of osteomalacia (Itai-Itai when concentration of Cd reached or exceeded 200 g/g
In Japan, excessive cadmium in the diets of some older women has caused "itai-itai"--or "ouch-ouch" disease.
Combined effects of estrogen deficiency and cadmium exposure on calcified hard tissues: Animal model relating to itai-itai disease in postmenopausal women Mitsuo Kakei, Toshiro Sakae and Masayoshi Yoshikawa Communicated by Tatsuo Suda, M.J.A.
Itai-itai (ouch-ouch) disease caused by cadmium (Cd) exposure is considered a type of osteomalacia, and is characterized by increased osteoid formation, with low-grade bone mineralization.
Man being at the top of many food chains is highly vulnerable as in the cases of Cd and Hg poisoning (Itai-itai and Rheumatic diseases) in the Jintsu River and Minamata, Japan [11,20].
The typical patient with itai-itai disease was reported to be a middle aged postmenopausal multiparous woman who had lumbar pains, leg myalgia, and ducklike gait.