itai-itai disease

i·tai-·i·tai dis·ease

a form of cadmium poisoning described in some Japanese people, characterized by renal tubular dysfunction, osteomalacia, pseudofractures, and anemia, caused by ingestion of contaminated shellfish or other sources containing cadmium.

A form of renal osteodystrophy—osteomalacia with marked bone pain and painful fractures—described in multiparous Japanese women due to cadmium accumulation in bone, caused by industrial pollutants