isozyme

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isoenzyme

[i″so-en´zīm]

any of several forms of an enzyme that all catalyze the same reaction but may differ in reaction rate, inhibition by various substances, electrophoretic mobility, or immunologic properties. Several enzymes, particularly alkaline phosphatase, lactate dehydrogenase, and creatine kinase, have clinically important isoenzymes. Isoenzymes are separated by electrophoresis, and the pattern indicates which damaged organ has released the enzymes.

i·so·en·zyme

(ī'sō-en'zīm),

An enzyme (one of a group) that catalyze the same reaction but may be differentiated by variations in physical properties, such as isoelectric point, electrophoretic mobility, kinetic parameters, or modes of regulation, for example, lactate dehydrogenase, a tetramer composed of varying amounts of α and β subunits (that is, 4α, 3α + 1β, 2α + 2β, 1α + 3β, and 4β).

Synonym(s): isozyme

Farlex Partner Medical Dictionary © Farlex 2012

isozyme

(ī′sə-zīm′)

An isoenzyme.

i′so·zy′mic adj.

i·so·en·zyme

(ī'sō-en'zīm)

One of a group of enzymes that catalyze the same reaction but may be differentiated by variations in physical properties, such as isoelectric point, electrophoretic mobility, kinetic parameters, or modes of regulation.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

isozyme

see ISOENZYME.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

References in periodicals archive ?

Christianson, X-ray crystallographic studies of mammalian carbonic anhydrase isozymes, Carb.

Tyrosinase and Carbonic Anhydrase Enzymes Inhibition Studies of Vanadium(V) Complexes

Isoenzymes expression: The induction of new isozymes and the change in the isoenzymes profiles play an important role in the cellular defense against oxidative stress.

ALLEVIATION OF OXIDATIVE EFFECTS OF SALT STRESS IN WHITE LUPINE (LUPINUS TERMIS L.) PLANTS BY FOLIAR TREATMENT WITH L-ARGININE

With the exception of residue 67, the majority of residues in the 5 - 10 A zone remain conserved between the isozymes. This observation is reinforced by the lack of selectivity observed for compact CAIs that bind deep within the active site.

Crystallography and Its Impact on Carbonic Anhydrase Research

Histidine, phenylalanine, sildenafil citrate have been shown to be potential activators of different CA isozymes. D-3,4-dihydroxyphenylalanine; dextrodopa (D-DOPA), L-Tyr, and 4-amino-L-Phe act as perfect activators for CAs like the histamine.

Activation of Two Different Drugs Used in Alzheimer's Disease Treatment on Human Carbonic Anhydrase Isozymes I and II Activity: an In Vitro Study/Alzheimer Hastaliginin Tedavisinde Kullanilan Iki Farkli Ilacin Insan Karbonik Anhidraz I ve II Izoenzim Aktiviteleri Uzerindeki Aktivasyonu: In Vitro Calisma

Reproductive implications of LDH-C4 and other testis-specific isozymes. Exp.

Expression of Ldh-c (Sperm-Specific Lactate Dehydrogenase Gene) in Skeletal Muscle of Plateau Pika, Ochotona curzoniae, and its Effect on Anaerobic Glycolysis

The highest enzymatic activity was belonged to tolerant group under severe stress conditions for almost all of isozymes reported.

Differential antioxidant isozyme response from desiccation induced oxidative stress of the forked fern (dicranopteris linearis)

Gamma rays and JA treatments caused changes in activities, the band concentration of peroxidase and polyphenol oxidase isozymes and increase amino acid contents.

Role of Jasmonic Acid and Gamma Radiation in Alleviating Salt Stress in Moringa

The predominance of U-LDH1 and U-LDH2 isozymes in the acute phase of KD is thought to be derived from the kidney and urinary tract.

Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease

We then investigated the involvement of CYPs in the metabolism of LDT5, using the human CYP1A2, 2C9, 2C19, 2D6 and 3A4 isozymes. To summarize our results (Table 2), LDT5 was found to be a substrate of CYP2D6 with a half-life of 5 min and CYP2C19 with a half-life of 20 min.

ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia

We used isozymes, plastid, and nuclear DNA sequences of samples collected within the three species' natural ranges to answer these questions.

Hibridacion local en habitats de montana subtropicales: ?Cedrela (Meliaceae) puede mantener la identidad de las especies en simpatria?

Almost all types of molecular markers have been tested in chickpea including isozymes (7,15), restriction fragment length polymorphism (RFLP) (44), random amplified polymorphic DNA markers (RAPDs) (12), amplified fragment length polymorphisms (AFLPs) (28), sequence characterized amplified regions (SCARs) (19), inter-simple sequence repeat (ISSRs) (12), simple sequence repeat (STMS or SSR) (18,29), resistance gene analogs (RGAs)10, DNA amplification fingerprinting (DAF) (2) and expressed sequence tags (ESTs) (31).

Molecular assisted breeding for Ascochyta blight resistance in Chickpea (Cicer arietinum L.)--A review

Drug-metabolizing enzymes include many cytochrome P450 isozymes and others.

Drug-Metabolizing Enzymes and Metabolic Diseases: Role of Antioxidants

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