In addition, limonene has well-established chemopreventive activity against many types of cancer, inhibiting protein isoprenylation
and cell growth (Poon et al.
The role of isoprenylation
in membrane attachment of nuclear lamins.
Limonene arrests parasite development and inhibits isoprenylation
of proteins in Plasmodium falciparum.
Upon inhibition of mevalonate synthesis, statins not only inhibit cholesterol synthesis but also the isoprenylation
of key proteins in the inflammatory cascade.
3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation
inhibitors induce apoptosis of vascular smooth muscle cells in culture.
The mechanism underlying this effect of atorvastatin is probably related to inhibition of nuclear factor-[kappa]B activity secondary to a decrease in isoprenylation
of proteins involved in intracellular signal transduction necessary for their correct function, because COX-2 is controlled by this transcription factor, and it has been confirmed that statins can directly decrease nuclear factor-[kappa]B activity (15).
She received the prize for her dissertation: "The Importance of Isoprenylation
and Nf1 Deficiency in KRASinduced Cancer".
Identification of metabolites of the antitumor agent D-limonene capable of inhibiting protein isoprenylation
and cell growth.
Discovery of ubiquinone-1, -2, -3, and -4 and the nature of isoprenylation
It is well documented that many monoterpenes inhibit isoprenylation of proteins, which occurs at the level of prenyl-protein transferase enzyme (Crowell et al.
Crowell PL, Chang RR, Ren Z, Elson CE, Gould MN (1991) Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-Limonene and its metabolites.
Crowell PL, Ren Z, Lin S, Vedejs E, Gould MN (1994) Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation.