prenylation

(redirected from Isoprenylation)

pre·nyl·a·tion

(pre'nil-ā'shŭn),
The covalent addition of prenyl and multiprenyl residues to a macromolecule.
References in periodicals archive ?
Many small guanosine triphosphate hydrolases (GTPases) that participate in tumorigenesis, such as RAS and RHO proteins, are isoprenylated, and the inhibition of this pathway can reduce the isoprenylation of these small GTPases.
One fact leading to suppressive effects in inflammatory processes is that by inhibiting mevalonate synthesis, isoprenylation of small GTP-binding proteins is also inhibited, which is required for maintaining NADPH oxidase activity [58] and Ras-like proteins (Rho, Rac).
Isoprenylation of ubiquinone is important for OXPHOS and isoprenylation of Ras, Rho, and Rab guanosine triphosphatases is involved in immunological synapse formation, migration, proliferation, and cytotoxic effector response of T cells.
Caponigro, "Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: Preclinical and clinical implications," Current Drug Targets, vol.
We also demonstrated that aspects of this inhibition, for example, protein isoprenylation and geranylation, could be reversed by replenishment of depleted isoprene precursors [7].
Isoprenylation is responsible for the high lipophilic nature of this molecule that is ubiquitous in biological membranes, and therefore, it is also known as ubiquinone.
They also suppress the mevalonate pathway and isoprenylation of small G proteins, leading to tumor regression [59].
Most pleiotropic effects of statins are thought to be related to inhibition of the mevalonate-dependent isoprenylation of small guanosine triphosphate (GTP)-binding proteins, such as Rho, Ras, and Rac 1.
This may be explained by the antioxidant effects of simvastatin, as a result of inhibition of mevalonate pathway causing a significant reduction in the biosynthesis of important intermediates, like isoprenoids, which act as a lipid attachment/anchoring for intracellular signaling molecules, particularly the inhibition of the small GTPase binding proteins whose proper membrane localization and function are dependent on isoprenylation. (15)
For their part, the membrane localization and activation of Ras, RhoA, and Racl depend on the process of isoprenylation [35-37].
In addition, limonene has well-established chemopreventive activity against many types of cancer, inhibiting protein isoprenylation and cell growth (Poon et al., 1996; Vigushin et al., 1998).
The inhibitory effect of terpenes and S-farnesylthiosalicylic acid on the biosynthesis of both dolichol, the isoprenic side chain of ubiquinones, and the isoprenylation of proteins in the intraerythrocytic stages of P falciparum appears to be specific, because overall protein biosynthesis was not affected.