isoenzyme

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isoenzyme

 [i″so-en´zīm]
any of several forms of an enzyme that all catalyze the same reaction but may differ in reaction rate, inhibition by various substances, electrophoretic mobility, or immunologic properties. Several enzymes, particularly alkaline phosphatase, lactate dehydrogenase, and creatine kinase, have clinically important isoenzymes. Isoenzymes are separated by electrophoresis, and the pattern indicates which damaged organ has released the enzymes.

i·so·en·zyme

(ī'sō-en'zīm),
An enzyme (one of a group) that catalyze the same reaction but may be differentiated by variations in physical properties, such as isoelectric point, electrophoretic mobility, kinetic parameters, or modes of regulation, for example, lactate dehydrogenase, a tetramer composed of varying amounts of α and β subunits (that is, 4α, 3α + 1β, 2α + 2β, 1α + 3β, and 4β).
Synonym(s): isozyme

isoenzyme

(ī′sō-ĕn′zīm′)
n.
An isoform that is an enzyme.

i′so·en·zy′mic adj.

i·so·en·zyme

(ī'sō-en'zīm)
One of a group of enzymes that catalyze the same reaction but may be differentiated by variations in physical properties, such as isoelectric point, electrophoretic mobility, kinetic parameters, or modes of regulation.

isoenzyme (isozyme)

one of a number of ENZYMES that catalyse the same reaction, but are qualitatively different from each other, for example in PRIMARY STRUCTURE.

Isoenzyme

One of a group of enzymes that catalyze the same reaction but are differentiated by variations in physical properties.
References in periodicals archive ?
The utility of Lactate dehydrogenase isoenzyme pattern in the diagnostic evaluation of malignant and non-malignant ascites.
The presence of fragmented parts of bone and liver isoenzymes of ALP and atypical ALP in serum supports the hypothesis of inadequate removal of ALP from the circulation during viral infections (9).
Deficiencies of N-acetyl-[beta]-hexosaminidase A and B isoenzyme activities in neonatal body are the reason for storing glycoconjugates in their lysosomes that cause Sandhoff and Tay-Sachs diseases [11].
Electrophoresis analysis of isoenzymes is known to provide a reliable assessment in testing genetic purity of hybrids and inbred lines of maize (Orman et al., 1991; Wang et al., 1994).
In light of the above information, we thought that these drugs could activate hCAI and II isoenzymes. We have purified hCAI and hCAII from human erythrocytes and analyzed the in vitro effects of these drugs memantine (1) and donepezil (2) on these isoenzymes.
GPBB isoenzyme is released into bloodstream via the T-tubules system with the peak value within the first 4 h after the onset of chest pain.
Different garlic preparations have shown diverse and highly variable results of the effects of CYP isoenzymes and metabolism
Electrophoresis was conducted at the same voltage as esterase isoenzyme electrophoresis, and the gel was stained using the method described in the study by Li et al.
Serum b2m and LD2 isoenzyme levels were determined in the subjects and the values were compared with healthy age and sex matched controls.
Various studies have reported that autoantibodies to CA isoenzymes increase during the course of some immunological diseases.
Acetylation by aspirin is also occurring on the COX-2 isoform in almost the same manner due to the structural homology between COX-1 and COX-2 isoenzymes. Tyrosine residues (tyr-385) to a greater extent and (tyr-348) to a lesser extent are critical for this acetylation event of COX-2 by aspirin [26].