Inflammatory tinea pedis with bacterial superinfection effectively treated with isoconazole
nitrate and diflucortolone valerate combination therapy.
Antifungal agents are either polyenes (nystatin and am-photericin B) or azoles which are classified into: imidazoles (clotrimazole, econazole, fenticonazole, isoconazole
, ketocon-azole, miconazole, sulconazole, tioconazole); and triazoles (fluconazole, itraconazole).
In gram-positive bacteria, accumulation of single oxygen species was observed after incubation with isoconazole nitrate (TravogenA/ TravocortA).
Isoconazole nitrate displays a broad spectrum of antimicrobial action against dermatophytes, yeasts, moulds and gram-positive bacteria.
Our data suggest that the bactericidal action of imidazoles such as isoconazole nitrate on gram-positive bacteria is based on the accumulation of reactive oxygen species, said Dr.
In Switzerland, three triazoles (terconazole, itraconazole, fluconazole) and eight imidazoles (clotrimazole, miconazole, econazole, ketoconazole, tioconazole, isoconazole
, oxiconazole, and fenticonazole) are in use (Documed AG 2002).