In glial tumors, point mutations at codon 132 in the isocitrate
dehydrogenase (IDH) 1 gene (human cytosolic nicotinamide adenine dinucleotide phosphate hydrogen-dependent isocitrate
dehydrogenase 1) may be observed.
The product is a first-in-class, oral, potent and selective inhibitor of the mutant isocitrate
Prescribing Information for TIBSOVO, an isocitrate
dehydrogenase-1 inhibitor, to include adult patients with newly diagnosed acute myeloid leukemia with a susceptible IDH1 mutation as detected by an FDA-approved test who are greater than or equal to 75 years old or who have comorbidities that preclude use of intensive induction chemotherapy.
Tibsovo (ivosidenib), which has a MW of 583, is an isocitrate
dehydrogenase 1 inhibitor used for patients with relapsed or refractory AML.
The researchers focused on low-grade gliomas that carry a disease-causing mutation in a gene called isocitrate
dehydrogenase 1 (IDH1), which encodes a protein known to help cells produce energy.
In 2012 Yip et al., further analyzed chromosomal mutations of 1p/19q and genes encoding isocitrate
dehydrogenase (IDH) as diagnostic markers for ODs.9 Lecavalier-Barsoumet al., in 2014, systematically reviewed treatment modalities for anaplastic oligodendrogliomas with the aim of establishing the predictive and prognostic value of markers such as 1p/19q co-deletion.10 To this effect PCV prior to RT increased mean overall survival, with the subset of ODs with 1p/19q chromosomal codeletion showing increased sensitivity to combined PCV with RT.
Correlation Between Isocitrate
Dehydrogenase Gene Aberrations and Prognosis of Patients with Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis.
* The advent of in-depth tumor gene sequencing has given scientists insights into mutations in a gene known as isocitrate
dehydrogenase, or IDH, which usually make gliomas significantly less aggressive than gliomas with a normal IDH gene.
Briefly, this complex enhances the enzymatic activities of Krebs cycle enzymes, isocitrate
dehydrogenase, [alpha]-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase and mitochondrial respiratory enzymes, complex I, complex II, complex III, and complex IV.
In particular, the identification of driver mutations in glioblastoma, such as isocitrate
dehydrogenase (IDH) mutations, has prompted large-scale studies defining their usefulness as biomarkers for diagnosis/classification, prognostication, and treatment decisions for brain tumors.
During this period, isocitrate
dehydrogenase mutation was discovered and methylguanine methyltransferase (MGMT) repair enzyme was identified.
Spectrophotometric assays were used to determine the activity of glucose 6-phosphate dehydrogenase (G6PDH) , isocitrate
dehydrogenase (ICDH) , malate dehydrogenase (MDH) , and malic enzyme (ME) .