Ismo


Also found in: Dictionary, Acronyms.

isosorbide dinitrate

Angitak (UK), Apo-ISDN (CA), Cedocard (UK), Cedocard-SR (CA), Dilatrate-SR, Isochron, Isoket (UK), Isordil Titradose, Novo-Sorbide (CA), PMS-Isosorbide (CA), Soni-Slo SR, Sorbid

isosorbide mononitrate

Angeze (UK), Chemydur (UK), Cibral (UK), Cibral XL (UK), Dynamin (UK), Dynamin XL (UK), Elantan (UK), Elantan LA (UK), Imazin XL (UK), Imdur (UK), Imo LA (UK), Isib (UK), ISMO (UK), Isodur (UK), Ketanodur (UK), Modisal (UK), Monigen (UK), Monigen XL (UK), Monit (UK), Monit LS (UK), Monoket (UK), Monomax (UK), Monomax SR (UK), Monomax XL (UK), Monomil (UK), Monosorb (UK), Trangina (UK), Trangina XL (UK), Xismox (UK), Zemon (UK), Zemon XL (UK)

Pharmacologic class: Nitrate

Therapeutic class: Antianginal

Pregnancy risk category C

Action

Promotes peripheral vasodilation and reduces preload and afterload, decreasing myocardial oxygen consumption and increasing cardiac output. Also dilates coronary arteries, increasing blood flow and improving collateral circulation.

Availability

isosorbide dinitrate

Capsules: 40 mg

Capsules (extended-release): 40 mg

Tablets: 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, 40 mg

Tablets (chewable): 5 mg, 10 mg

Tablets (extended-release): 20 mg, 40 mg

Tablets (sublingual): 2.5 mg, 5 mg, 10 mg

isosorbide mononitrate

Tablets: 10 mg, 20 mg

Tablets (extended-release): 30 mg, 60 mg, 120 mg

Indications and dosages

Treatment and prophylaxis in situations likely to provoke acute angina pectoris

Adults: 2.5 to 5 mg S.L. May repeat dose q 5 to 10 minutes for a total of three doses in 15 to 30 minutes.

Prophylaxis of angina pectoris

Adults: 5 to 40 mg P.O. (dinitrate conventional tablets) two to three times daily. Or 5 to 20 mg (mononitrate conventional tablets) b.i.d. Or 30 to 60 mg (mononitrate extended-release tablets) once daily. After several days, dosage may be increased to 120 mg (given as single 120-mg tablet or two 60-mg tablets) once daily. Rarely, 240 mg/day (mononitrate extended-release tablets) may be needed.

Off-label uses

• Heart failure

Contraindications

• Hypersensitivity to drug

• Severe anemia

• Acute myocardial infarction

• Angle-closure glaucoma

• Concurrent sildenafil therapy

Precautions

Use cautiously in:

• head trauma, volume depletion

• elderly patients

• pregnant or breastfeeding patients

• children.

Administration

• Give oral form 30 minutes before or 1 to 2 hours after a meal. Make sure patient swallows tablets or capsules whole.

• Have patient wet S.L. tablet with saliva before placing it under tongue. To avoid tingling sensation, have him place tablet in buccal pouch.

Adverse reactions

CNS: dizziness, headache, apprehension, asthenia, syncope

CV: orthostatic hypotension, tachycardia, paradoxical bradycardia, rebound hypertension

EENT: sublingual burning (with S.L. route)

GI: nausea, vomiting, dry mouth, abdominal pain

Skin: flushing

Interactions

Drug-drug. Aspirin: increased isosorbide blood level and effects

Beta-adrenergic blockers, calcium channel blockers, phenothiazines: additive hypotension

Dihydroergotamine: antagonism of dihydroergotamine effects

Sildenafil: severe and potentially fatal hypotension

Drug-diagnostic tests. Cholesterol: decreased level

Methemoglobin, urine vanillylmandelic acid: increased levels

Patient monitoring

• Monitor ECG and vital signs closely, especially blood pressure.

In suspected overdose, assess for signs and symptoms of increased intracranial pressure.

• Monitor arterial blood gas values and methemoglobin levels.

Patient teaching

• Teach patient to take oral drug 30 minutes before or 1 to 2 hours after a meal.

• Inform patient that drug may cause headache. Advise him to treat headache as usual and not to alter drug schedule. If headache persists, tell him to contact prescriber.

• Instruct patient to move slowly when sitting up or standing, to avoid dizziness or light-headedness from sudden blood pressure decrease.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Ismo

A brand name for ISOSOBIDE MONONITRATE.
References in periodicals archive ?
Como vimos, os valores e praticas que configuram o que indicamos como o ismo no campo jornalistico tem como importantes matrizes culturais discursos, formatos e logicas produtivas que remontam pelo menos a decada de 1950 no Brasil.
He said that programmes like ISMO, help in intellectual growth of students.
In order to provoke interest among the students, PAKTURK International Schools and Colleges have been arranging Inter Schools Mathematics Olympiads (ISMO) for the last 10 years.
The Minister was addressing the Prize distribution ceremony of Pakistan's largest mathematics Olympiad ISMO (Inter Schools Mathematics Olympiad), here at a local hotel, said a press release.
Ex-Utrecht defender Ismo Vorstermans will play against Energie Cottbus in Germany tonight, while French central defender Jean Yves Koue will join Jackie McNamara's squad in Spain next week.
The buyer is the company's managing director Ismo Raty, Ruukki said.
With: Magnus Krepper, Sverrir Gudnason, Johanna Lazcano Osterman, Ann-Sofie Rase, Tord Peterson, Anders Palm, Eva Fritjofson, Kristoffer Pianadai, Rolf Lydahl, Henrik Lundstrom, Adam Jonasson, Ismo Nurmilehto, Tomas Ostling.
Finnish computer expert Ismo Rakkolainen's technique generates fog walls made from dry ice pumped between two layers of fast-moving air a centimetre apart.
Additionally, American Home Products Corp.'s Ismo (an analgesic for chest pains), Merck & Co.'s Zocor (a cholesterol-lowering treatment) and SmithKline Beecham PLC's Relafen arthritis treatment were given the go-ahead.
This year PAKTURK International Schools and Colleges organized (ISMO) with the collaboration of Pakistan Science Foundation.
In Federal Capital, the contest was held at Chak Shahzad, H-8 and G-10 campuses.The purpose of the ISMO was to promote interest and excellence in mathematics, besides encouraging the talent.
ISLAMABAD -- The 9th National Inter Schools Maths Olympiad (ISMO) concluded on Monday with success and record participation of around 11,000 students.