islet transplantation

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islet transplantation

An alternative to pancreatic transplantation in patients whose conventional diabetic control is threateningly poor and whose risk of diabetic complications and shortening of life is considered high. A lesser degree of immunosuppression is required than panceras transplantation and the surgery is minor. Purified ISLETS OF LANGERHANS are digested from a donor pancreas and are infused through a catheter passed through the liver into the portal vein from whence the islets pass into the sinusoids of the liver. The method is still considered experimental.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
In animal islet cell transplantation models, the density of the grafts' cholinergic innervation when implanted in the liver, spleen, or renal capsule was significantly lower than those islets in situ; however, there were no significant differences in the density of the grafts' adrenergic innervations [8].
Chaikof, "Engineering and material consideration in islet cell transplantation," Annual Review of Biomedical Engineering, vol.
Gillard et al., "Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients," Diabetes, vol.
"Last year saw the launch of our bone marrow transplantation program and currently we are at the final stage of preparation to launch pancreas transplantation and islet cell transplantation. The wider organ donation and transplantation program continues to evolve to meet the changing needs of our community and has been striving to fulfill its vision to provide the best quality care for all patients, irrespective of nationality, religion, or race."
Weir, "Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice," The Journal of Clinical Investigation, vol.
Now, a new advancement from MIT, Boston Children's Hospital, and several other institutions may offer a way to fulfill the promise of islet cell transplantation. The researchers have designed a material that can be used to encapsulate human islet cells before transplanting them.
The cells function so well under these conditions, in fact, that the method requires significantly fewer cells to be effective than standard islet cell transplantation into the liver--as much as one-third or one-fourth the amount.
Now, a new advance from MIT, Boston Children's Hospital, and several other institutions may offer a way to fulfill the promise of islet cell transplantation. The researchers have designed a material that can be used to encapsulate human islet cells before transplanting them.
Is islet cell transplantation or regeneration from stem cells a possible treatment?
The final section is devoted to islet cell transplantation. Ernesto Pompeo Molmenti is a practicing physician and surgeon, and a faculty member of the LIJ School of Medicine, New York.
The company believes that converting the diabetic patient's own tissue into insulin-producing cells has the potential to overcome the significant issues of donor shortage, cost and exposure to chronic immunosuppressive therapy associated with islet cell transplantation.
123 EMERGING NEW DIABETES TREATMENT STRATEGIES: BETATROPHIN VERSUS ISLET CELL TRANSPLANTATION