Isaacs' syndrome


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Isaacs' syndrome

[ī′zəks]
Etymology: H. Isaacs, American neurologist, 20th century
progressive muscle stiffness and spasms, with continuous muscle fiber activity similar to that seen with neuromyotonia. Compare stiff-man syndrome.
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Isaacs' syndrome is characterized by spontaneous and persistent muscle-fibre activity that may result in continuous muscle twitching and rippling movements of the muscles that can be regular or irregular.
Isaacs' syndrome may occur as a paraneoplastic manifestation of malignancies such as small-cell lung carcinoma, Hodgkin's lymphoma, plasmacytoma with IgM paraproteinaemia and bladder carcinoma (2,22).
Reversible F-wave hyperexcitability associated with antibodies to potassium channels in Isaacs' syndrome.