Isaac syndrome

Isaac syndrome

(ī'sik),
a rare disorder resulting from abnormal, spontaneous muscle activity of neural origin, manifested as continuous muscle stiffness and delayed relaxation after exercise, often accompanied by pain, cramps, fasciculations, hyperhydrosis, and muscle hypertrophy (on EMG, manifests as myokymia). Isacc syndrome usually begins in the lower extremities but can affect abdominal, upper extremity, vocal, and respiratory muscles; it is most often sporadic, although autosomal dominant inheritance has been reported. Probably an autoimmune disease, with antibodies against the potassium channels of peripheral nerves.

Isaac syn·drome

, Isaac-Merton syndrome (ī'zăk sin'drŏm, ī'zăks mār'tŏn sin'drōm)
A rare disorder resulting from abnormal, spontaneous muscle activity of neural origin, manifested as continuous muscle stiffness and delayed relaxation after exercise, often accompanied by pain, cramps, fasciculations, hyperhydrosis, and muscle hypertrophy (on electromyography, manifests as myokymia). Disorder usually begins in the lower extremities but can affect abdominal, upper extremity, vocal, and respiratory muscles; it is most often sporadic, although autosomal dominant inheritance has been reported. Probably it is an autoimmune disease, with antibodies against the potassium channels of peripheral nerves.

Isaac syndrome

(i'zaks)
A rare neuromuscular disorder in which continuous signaling of muscle groups by peripheral nerves results in fasciculations, stiffness, and dysarthria. It can be treated with antiepileptic drugs.
Synonym: neuromyotonia
References in periodicals archive ?
Hareven first referred to "our primary myth c violence" in a 1976 essay named "Alimut [Violence] (3) In this essay she conducted dialogue with one of Israel's bites noires the criminologist and social critic, Shlomo Giora Shoham--who year earlier had published, in both Israel and America, a rather controversial article, "The Isaac Syndrome.
Shlomo Giora Shoham, "The Isaac Syndrome," American Imago 33:4, 329-349.